EFFECTS OF CASTRATION AND SILASTIC IMPLANTS OF TESTOSTERONE ON INTERMALE AGGRESSION IN MOUSE
EFFECTS OF CASTRATION AND SILASTIC IMPLANTS OF TESTOSTERONE ON INTERMALE AGGRESSION IN MOUSE
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DOI：
10.1016/0018-506x(77)90048-4
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发表时间：
1977-01-01
影响因子：
3.5
通讯作者：
GOLDMAN, BD
中科院分区：
文献类型：
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作者：
BARKLEY, MS;GOLDMAN, BD
用去势和睾酮(T)替代的方法研究雄激素刺激下攻击性行为反应的发育变化。出生时被去势的雄性小鼠对循环T的敏感度低于青春期前或成年去势，但在新生的去势小鼠中，用一定剂量的雄激素诱导了打斗，导致成年去势小鼠的附属器官系统肥大。性腺切除在青春期前不久血清T浓度升高也降低了对雄激素注射的行为反应。在青春期前的去势中，只有在成年去势的辅助器官保持生长的情况下，T处理才能诱导雄性间攻击。在青春期血清T激增后被阉割的雄性动物的攻击性行为得到了循环中的雄激素水平的支持，雄激素的循环水平未能刺激辅助器官系统，而不是油处理的去势雌性动物。新生儿或青春期的T刺激对于调节最终表达男性间攻击性的神经底物的组织并不是完全关键的，但从出生起就暴露在青春期发育过程中通常需要对成年后遇到的循环T产生最大的攻击性行为反应。
Castration and testosterone (T) replacement were used to study developmental changes in aggressive behavioral responsiveness to androgenic stimulation. Male mice castrated at birth were less sensitive to circulating T than were prepubertal or adult castrates, but fighting was induced in neonatal castrates with a dose of androgen that produced hypertrophy of the accessory organ system in adult castrates. Gonadectomy shortly prior to pubertal increases in serum T concentration also reduced behavioral responsiveness to androgen administration. Intermale aggression was induced in prepubertal castrates only with T treatment that maintained accessory organ growth in adult castrates. The aggressive behavior of males castrated after the pubertal surge in serum T was supported with circulating levels of androgen that failed to stimulate the accessory organ system above that of oil-treated castrates. T stimulation during neonatal or pubertal life is not totally crucial for organization of neural substrates that mediate the ultimate expression of intermale aggression, but exposure to androgen from birth throughout pubertal development is normally required to produce maximal aggressive behavioral responsiveness to circulating T encountered in adulthood.