Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies.
Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies.
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DOI：
10.1007/1-4020-5466-1_3
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发表时间：
2007
影响因子：
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通讯作者：
David A. Wacker;Kristine M. Frizzell;Tong Zhang;W. Kraus
中科院分区：
文献类型：
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作者：
David A. Wacker;Kristine M. Frizzell;Tong Zhang;W. Kraus
聚(ADP-核糖)聚合酶-1(PARP-1)是PARP家族中最典型和表达最丰富的成员，它催化供体NAD+分子上的ADP-核糖(ADPR)单元聚合到靶蛋白上。PARP-1在多种基因组过程中发挥作用，包括对染色质结构的调节和对特定细胞信号的转录反应。PARP-1在许多应激诱导的疾病状态中也发挥着重要作用。在本章中，我们回顾了PARP-1‘S染色质调节活性的分子和细胞方面，以及这些染色质调节活性对基因表达调控的影响。此外，我们强调了靶向PARP-1‘S酶活性的药物在治疗人类疾病方面的潜在治疗用途。
Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases