Clinicopathological and immunohistochemical evaluation of oral squamous cell carcinoma in patients with early local recurrence
Clinicopathological and immunohistochemical evaluation of oral squamous cell carcinoma in patients with early local recurrence
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DOI：
10.1016/j.oraloncology.2006.07.003
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发表时间：
2007-07-01
期刊：
影响因子：
4.8
通讯作者：
de Almeida, Slei Paes
中科院分区：
文献类型：
--
作者：
Amanajas de Aguiar, Francisco Carlos, Jr.;Kowalski, Luiz Paulo;de Almeida, Slei Paes
局部早期复发是口腔鳞状细胞癌（OSCC）最终治疗失败的主要原因之一，是这种肿瘤相对较低生存率的重要原因。本研究的目的是探讨OSCC局部早期复发的临床、组织学和分子因素，以便更好地对某些特定病例进行风险评估。27例早期复发OSCC患者与54例具有相同临床分期和肿瘤部位但未局部复发的患者进行配对研究设计。评估AR病例的临床病理特征和Ki-67、p53、bct-2、FAS、erbb - b2、β -catenin、E-cadherin的免疫组织化学表达。与ELR相关的变量是饮酒（p= 0.019）、治疗（p= 0.041）、Ki-67 （p=0.028）、FAS （p= 0.005）和膜β -连环蛋白（p= 0.026）的表达。多因素生存分析（Cox回归）显示，手术配合辅助放疗[OR = 0.26 (95% Cl, 0.1-0.6)]和FAS表达[OR = 0.21 (95% Cl, 0.1-0.5)]对ELR的发展有显著影响。放疗对患者的总生存期无显著影响。因此，肿瘤的治疗和分子特征似乎都与早期局部复发有关。(c) 2006 Elsevier Ltd.版权所有。
Early local recurrence is one of the main causes of treatment failure after definitive therapy of oral squamous cell carcinoma (OSCC), contributing significantly for the relative low survival rates of this neoptasia. The aim of this study was to investigate the clinical, histological and molecular factors involved in early local recurrence of OSCC, which may lead to better risk assessment in some specific cases. Twenty-seven patients with early recurrent OSCC were matched with 54 patients with the same clinical stage and tumor site but without local recurrence, in a pair-matched study design. AR cases were evaluated in relation to the clinico-pathotogical features and immunohistochemical expression of Ki-67, p53, bct-2, FAS, Erb-B2, beta-catenin, and E-cadherin. The variabies associated with ELR were alcohol consumption (p = 0.019), treatment performed (p = 0.041), and expression of Ki-67 (p=0.028), FAS (p = 0.005) and membrane beta-catenin (p = 0.026). The multivariate survival analysis (Cox regression) showed that surgery with adjuvant radiotherapy [OR = 0.26 (95% Cl, 0.1-0.6)] and FAS expression [OR = 0.21 (95% Cl, 0.1-0.5)] had a significant effect for ELR development. Radio-therapy had no significant impact on patients' overall survival. Therefore, both treatment and motecular characteristics of the tumor seem to be involved in early local recurrence. (c) 2006 Elsevier Ltd. Alt rights reserved.