Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits
Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits
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泰山马尾松花粉多糖对家兔出血性疾病组织灭活疫苗免疫应答及对獭兔生产性能的影响
DOI：
10.1016/j.vaccine.2011.01.068
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发表时间：
2011-03-21
期刊：
影响因子：
5.5
通讯作者：
Zhu, Ruiliang
中科院分区：
文献类型：
--
作者：
Wei, Kai;Sun, Zhenhong;Zhu, Ruiliang
采用热水浸提醇沉法提取泰山马尾松花粉多糖（TPPPS）和黄芪多糖（APS），并将其加入疫苗中，制备多糖-兔出血症（RHD）组织灭活疫苗。研究TPPPS对RHD组织灭活疫苗免疫效果及对雷克斯兔生产性能的影响。结果表明，Ⅰ、Ⅱ、Ⅲ、Ⅳ组各项指标均高于Ⅴ组，尤其Ⅰ、Ⅱ、Ⅳ组与Ⅴ组差异更显著I组各项指标均显著高于V组（P < 0.05）I组各项指标均显著高于HMI组（P <0.05），II组与III组间无显著性差异。第四组的总体水平略低于第一组。多糖组各项指标达到峰值的时间晚于非多糖组。结果表明，TPPPS任何剂量均可提高家兔的免疫功能和生产性能，其中以400 mg/只的效果最为明显。延长RHD组织灭活疫苗免疫高峰期和雷克斯兔生长高峰期。TPPPS的效率通常高于APS。(C)2011爱思唯尔有限公司保留所有权利。
Varied doses of Taishan Pinus massoniana pollen polysaccharide (TPPPS) and Astragalus polysaccharide (APS) extracted by hot water extraction and ethanol precipitation method were added to the vaccine in order to prepare polysaccharide-rabbit haemorrhagic disease (RHD) tissue inactivated vaccine. The purpose was to study effects of TPPPS on immune response of RHD tissue inactivated vaccine and on production performance of Rex rabbits. Results showed that each index in groups I, II, III and IV was higher than that in group V. especially groups I, II and IV, the difference between which and group V was much more significant (P < 0.05); each index in group I was extremely higher than that in group V (P < 0.01); each index in group I was significantly higher than that in groups HMI (P < 0.05), and generally no significant difference was observed between groups II and III. The overall level in group IV was slightly lower than that in group I. Each index in the polysaccharide groups reached its peak value later than that in the non-polysaccharide groups did. Results suggested that any dose of TPPPS can enhance immunologic function and production performance of rabbits, and the amount of 400 mg per rabbit has the most obvious efficacy. Furthermore, it can extend the immune peak period of RHD tissue inactivated vaccine and the growing peak period of Rex rabbits. TPPPS has generally higher efficiency than APS. (C) 2011 Elsevier Ltd. All rights reserved.