Contrasting patterns of newer histocompatibility determinants in patients with rheumatoid arthritis and systemic lupus erythematosus.
Contrasting patterns of newer histocompatibility determinants in patients with rheumatoid arthritis and systemic lupus erythematosus.
复制标题
DOI：
10.1002/art.1780210920
复制
发表时间：
1978-06-01
影响因子：
--
通讯作者：
Kunkel, H G
中科院分区：
文献类型：
--
作者：
Gibofsky, A;Winchester, R;Kunkel, H G
在系统性红斑狼疮（SLE）或类风湿关节炎（RA）患者中测定了作为主要组织相容性复合体中不同等位基因的Ia异体抗原。所用试剂的Ia特异性是由它们与来自正常供体的HLA-D决定因子纯合子的淋巴母细胞系的反应模式确定的。试剂特异性包括与单一Dw类型相关的试剂，以及与几种Dw类型共享的单一特异性反应的试剂。RA患者在试剂血清中检测到的同种抗原的频率明显升高，这些抗原可识别HLA-Dw4、Dw7或Dw10个体细胞系共有的各种决定因素（i4-7-10）。混合淋巴细胞培养等位基因Dw4和Dw10的频率增加；然而，这种升高没有接近i47-10组血清学测定抗原的更高频率。相比之下，SLE患者与HLA-Dw2或Dw3阳性细胞系反应定义的试剂同种抗血清反应的频率增加。数据表明，免疫遗传因素与两组患者相关，但每种疾病的免疫遗传因素完全不同。
The Ia alloantigens as measures of different alleles of loci in the major histocompatibility complex were determined in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). The Ia specificities of reagents used were defined by their pattern of reaction with lymphoblastoid lines derived from normal donors homozygous for HLA-D determinants. The reagent specificities included those associated with a single Dw type as well as those reacting with a single specificity shared by several Dw types. Patients with RA had a marked elevation in the frequency of alloantigens detected by reagent sera that recognize various determinants shared by cell lines from HLA-Dw4, Dw7, or Dw10 individuals (Ia 4-7-10). The frequency of mixed lymphocyte culture alleles Dw4 and Dw10 was found to be increased; however this elevation did not approach the higher frequency for the serologically determined antigens of the Ia 4-7-10 group. In contrast, patients with SLE had an increased frequency of reactions with the reagent alloantisera defined by reactions with either HLA-Dw2 or Dw3 positive cell lines. The data suggest that immunogenetic factors are relevant to both groups of patients, but that these are entirely distinct for each disease.