Expression of Glut-1 is a prognostic marker for oral squamous cell carcinoma patients
Expression of Glut-1 is a prognostic marker for oral squamous cell carcinoma patients
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DOI：
10.3892/or_00000156
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发表时间：
2008-12-01
期刊：
影响因子：
4.2
通讯作者：
Bilkenroth, U.
中科院分区：
文献类型：
--
作者：
Eckert, A. W.;Lautner, M. H. W.;Bilkenroth, U.
口腔鳞状细胞癌（Oral squamous cell carcinoma，OSCC）是世界范围内第十大最常见的人类癌症之一，有证据表明其发病率和死亡率都在增加。尽管治疗方式取得了进展，但这种癌症的预后仍然很差，并且在过去二十年中没有改变。这项研究是基于从42例原发性口腔鳞癌患者中收集的样本。免疫组化法检测Glut-1的表达，并与临床病理资料进行比较。32名患者在其肿瘤中显示出弱的或检测不到的Glut-1表达，而在10名患者的肿瘤中检测到中等至强的Glut-1表达。在多变量考克斯回归风险分析中，肿瘤中Glut-1表达中度至强表达的患者与其他患者相比，肿瘤相关死亡风险增加4.9倍。我们的研究结果表明，Glut-1的表达是一个独立的预后指标，为口腔鳞癌的常规评估。
Oral squamous cell carcinoma (OSCC) is among the tenth most common human cancers worldwide with evidence of an increase in incidence rate and mortality. Despite advances in treatment modalities, the prognosis of this cancer is still very poor and has not changed over the past two decades. This study is based on samples collected from 42 patients with a primary OSCC. Immunohistochemical staining for Glut-1 was carried out and compared with the clinicopathological data. Thirty-two patients showed in their tumors a weak or undetectable Glut-l expression, whereas in tumors of 10 patients a moderate to strong Glut-1 expression was detected. In multivariate Cox's regression hazard analysis, patients whose tumors had a moderate to strong Glut-1 expression possessed a 4.9-fold increased risk of tumor-related death compared to the other patients. Our results suggest that Glut-1 expression is an independent prognostic marker for routine assessment of OSCC.