Tumor microenvironment in salivary gland carcinomas: An orchestrated state of chaos.
Tumor microenvironment in salivary gland carcinomas: An orchestrated state of chaos.
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DOI：
10.1016/j.oraloncology.2022.105777
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发表时间：
2022-02
期刊：
影响因子：
4.8
通讯作者：
E. Egal;J. Scarini;R. A. de Lima-Souza;L. Lavareze;P. Fernandes;C. Emerick;Mayara Trevizol Gonçalves-Mayara-Trevizol-Gonça
中科院分区：
文献类型：
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作者：
E. Egal;J. Scarini;R. A. de Lima-Souza;L. Lavareze;P. Fernandes;C. Emerick;Mayara Trevizol Gonçalves-Mayara-Trevizol-Gonça
涎腺癌(SGC)是一种形态异质性、组织学亚型较多的少见肿瘤。与其他肿瘤一样，SGC肿块由多种恶性细胞和多种免疫细胞、肿瘤相关成纤维细胞、细胞因子、趋化因子、细胞外基质蛋白和金属蛋白酶组成，统称为肿瘤微环境(TME)。这个混乱的网络是癌细胞生长的重要物理媒介。在这篇综述中，我们提供了对一些最常见的SGC的TME的最新见解。在这里，我们强调了这些肿瘤的组织异质性，描述了炎性浸润物的性质/强度，以及与每种SGC亚型相关的免疫逃逸机制。
Salivary gland carcinomas (SGC) are rare tumors of heterogeneous morphology and many histological subtypes. Like other tumors, the SGC mass consists of a varied population of malignant cells and a diverse array of immune cells, cancer-associated fibroblasts, cytokines, chemokines, extracellular matrix proteins, and metalloproteinases, collectively known as the tumor microenvironment (TME). This chaotic network serves as an important physical mediator of cancer cell growth. In this review, we provided current insights into the TME of some of the most common SGC. Here, we highlighted the histological heterogeneity of these tumors, delineated the nature/intensity of inflammatory infiltrates, and the mechanisms involved in immunological escaping related to each SGC subtype.