Apoptosis in heart transplantation
Apoptosis in heart transplantation
复制标题
心脏移植中的细胞凋亡
DOI：
10.1097/00019501-199710000-00004
复制
发表时间：
1997
影响因子：
1.8
通讯作者：
R. Shaddy
中科院分区：
文献类型：
--
作者：
R. Shaddy
细胞凋亡或程序性细胞死亡是细胞死亡的一种机制，在发育、稳态和许多疾病状态中起主要作用。细胞膜蛋白Fas与其配体Fas配体相互作用可诱导Fas携带细胞凋亡。哺乳动物心肌细胞凋亡的诱导因素包括再灌注损伤、缺氧、机械牵张、心肌梗死、快速心室起搏和高血压性心力衰竭。尽管在啮齿动物和人类的移植心脏中的研究已经表明心肌中存在Fas、Fas配体和凋亡，但是关于心脏移植后心肌中哪些细胞实际上正在经历凋亡存在争议。细胞凋亡与同种异体移植物排斥反应或移植后冠状动脉病变之间的关系（如果有的话）甚至更不清楚。本文综述了目前的知识，移植心脏细胞凋亡，并讨论了一些争议，围绕这个新的和迅速扩大的调查领域。
Apoptosis, or programmed cell death, is a mechanism of cell death that plays a major role during development, homeostasis, and in many disease states. The interaction of the cell membrance protein, Fas, with its ligand, Fas ligand, induces apoptosis in Fas-bearing cells. Several factors induce apoptosis in mammalian cardiomyocytes, including reperfusion injury, hypoxia, mechanical stretch, myocardial infarction, rapid ventricular pacing, and hypertensive heart failure. Although studies in the transplanted hearts of rodents and humans have shown the presence of Fas, Fas ligand, and apoptosis in the myocardium, there is controversy regarding which cells in the myocardium are actually undergoing apoptosis after heart transplantation. It is even less clear what type of relationship, if any, apoptosis has to allograft rejection or post-transplant graft coronary vasculopathy. This review summarizes the current knowledge regarding apopotosis in the transplanted heart and discusses some of the controversies surrounding this new and rapidly expanding area of investigation.