The role of vitamin D for bone health and fracture prevention.
The role of vitamin D for bone health and fracture prevention.
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DOI：
10.1007/bf02686953
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发表时间：
2006-09-01
影响因子：
4.3
通讯作者：
Holick, Michael F
中科院分区：
文献类型：
--
作者：
Holick, Michael F
维生素D缺乏是成年人的流行病。维生素D缺乏会导致骨量减少，加速和加重骨质疏松症，导致疼痛的骨病骨软化症，并增加肌肉无力，从而加剧跌倒和骨折的风险。维生素D缺乏症可以通过合理的阳光暴晒和充足的补充来预防。监测血清25-羟基维生素D是确定维生素D状态的唯一方法。最近的建议建议，在没有阳光照射的情况下，成年人每天应该摄入1000国际单位的维生素D3。25-羟基维生素D的理想健康血液水平应为30至60 ng/毫升。当25-羟基维生素D水平超过150毫微克/毫升时，就会发生维生素D中毒。最近的三份报告表明，补充维生素D和钙并不能降低骨折的风险，鉴于大量文献支持增加维生素D和钙的摄入量是降低脊椎和非椎骨骨折风险的有效方法，我们将对这三份报告进行展望。
Vitamin D inadequacy is pandemic in adults. Vitamin D deficiency causes osteopenia, precipitates and exacerbates osteoporosis, causes the painful bone disease osteomalacia, and increases muscle weakness, which worsens the risk of falls and fractures. Vitamin D deficiency can be prevented by sensible sun exposure and adequate supplementation. Monitoring serum 25-hydroxyvitamin D is the only way to determine vitamin D status. Recent recommendations suggest that in the absence of sun exposure, adults should ingest 1000 IU of vitamin D3 per day. The ideal healthy blood level of 25-hydroxyvitamin D should be 30 to 60 ng/mL. Vitamin D intoxication occurs when 25-hydroxyvitamin D levels are greater than 150 ng/mL. Three recent reports suggesting that vitamin D and calcium supplementation does not decrease the risk of fracture will be put into perspective in light of the vast literature supporting increasing vitamin D and calcium intake as an effective method for decreasing risk of vertebral and nonvertebral fractures.