Urine trouble: should we think differently about UTI?
Urine trouble: should we think differently about UTI?
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DOI：
10.1007/s00192-017-3528-8
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发表时间：
2018-02-01
影响因子：
1.8
通讯作者：
Brubaker, Linda
中科院分区：
文献类型：
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作者：
Price, Travis K.;Hilt, Evann E.;Brubaker, Linda
尿路感染(UTI)是成年女性最常见的细菌感染之一，具有重要的临床意义。然而，目前对尿路感染的理解仍然基于一个已经被证明是错误的概念，即膀胱是无菌的。因此，目前的尿路感染诊断标准有很大的局限性，这可能会减少改善患者护理的机会。使用我们的工作和许多其他同行评议的研究的数据，我们确定了当代UTI描述的四个主要限制：UTI的语言、UTI诊断测试、UTI的以大肠杆菌为中心的观点以及基于集落形成单位(CFU)阈值的诊断。现代的方法和技术，结合持续严格的临床研究，可以用来纠正这些局限性。
Urinary tract infection (UTI) is clinically important, given that it is one of the most common bacterial infections in adult women. However, the current understanding of UTI remains based on a now disproven concept that the urinary bladder is sterile. Thus, current standards for UTI diagnosis have significant limitations that may reduce the opportunity to improve patient care. Using data from our work and numerous other peer-reviewed studies, we identified four major limitations to the contemporary UTI description: the language of UTI, UTI diagnostic testing, the Escherichia coli-centric view of UTI, and the colony-forming units (CFU) threshold-based diagnosis. Contemporary methods and technology, combined with continued rigorous clinical research can be used to correct these limitations.