Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a, member of the resistance/nodulation/division efflux pump family
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a, member of the resistance/nodulation/division efflux pump family
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DOI：
10.1073/pnas.95.4.1829
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发表时间：
1998-02-17
影响因子：
11.1
通讯作者：
Lehrer, RI
中科院分区：
文献类型：
--
作者：
Shafer, WM;Qu, XD;Lehrer, RI
我们之前已经描述了蛋白蛋白-1 （PG-1）的抗菌能力，这是一种来自猪白细胞的富含半胱氨酸的阳离子肽，可以对抗淋病奈瑟菌。我们现在报告遗传和生化证据表明淋球菌对PG-1和其他结构无关的抗菌肽的致死性作用的易感性，包括由人粒细胞和睾丸组成表达并由角质形成细胞诱导的肽（LL-37），由称为mtr的能量依赖外流系统调节。这些结果表明，这种外排系统可能使淋球菌等粘膜病原体能够抵抗内源性抗菌肽，这些肽被认为在感染过程中起作用。
We have previously described the antibacterial capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-1 and other structurally unrelated antibacterial peptides, including a peptide (LL-37) that is expressed constitutively by human granulocytes and testis and inducibly by keratinocytes, is modulated by an energy-dependent efflux system termed mtr. These results indicate that such efflux systems may enable mucosal pathogens like gonococci to resist endogenous antimicrobial peptides that are thought to act during infection.