Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory
Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory
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DOI：
10.1016/j.neuroimage.2003.07.032
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发表时间：
2003-11-01
期刊：
影响因子：
5.7
通讯作者：
Stern, Y
中科院分区：
文献类型：
--
作者：
Habeck, C;Hilton, HJ;Stern, Y
认知储备(CR)被认为是一种机制，可以解释与衰老或神经退行性疾病相关的神经变化的临床表现的个体差异。CR可以代表个体在如何处理任务方面的差异(即，组成过程的差异)，或者是(组成过程的)基本神经回路的差异。CR可能是先天差异或不同生活经历的一种功能。为了研究认知能力在多大程度上可以解释大脑激活和任务表现的个体差异，我们使用fMRI对健康的年轻个体进行成像，同时执行一项非语言记忆任务。我们使用智商估计作为CR的替代指标。在任务的研究和测试阶段，我们识别了区域协方差模式，这些模式在两个任务条件下受试者表达的变化与成绩和认知能力相关。这两种激活模式中的共同大脑区域都暗示了之前发现的一个大脑网络，该网络是空间注意力公开和隐蔽转移的基础。在剔除任务绩效变量的影响后，该网络仍然与任务绩效相关，即存在与储备相关的生理差异，如果任务绩效没有被试差异，这种差异可能会持续下去。这表明该网络可能代表了CR的一种神经关联。(C)2003 Elsevier Inc.保留所有权利。
Cognitive reserve (CR) has been established as a mechanism that can explain individual differences in the clinical manifestation of neural changes associated with aging or neurodegenerative diseases. CR may represent individual differences in how tasks are processed (i.e., differences in the component processes), or in the underlying neural circuitry (of the component processes). CR may be a function of innate differences or differential life experiences. To investigate to what extent CR can account for individual differences in brain activation and task performance, we used fMRI to image healthy young individuals while performing a nonverbal memory task. We used IQ estimates as a proxy for CR. During both study and test phase of the task, we identified regional covariance patterns whose change in subject expression across two task conditions correlated with performance and CR. Common brain regions in both activation patterns were suggestive of a brain network previously found to underlie overt and covert shifts of spatial attention. After partialing out the influence of task performance variables, this network still showed an association with the CR, i.e., there were reserve-related physiological differences that presumably would persist were there no subject differences in task performance. This suggests that this network may represent a neural correlate of CR. (C) 2003 Elsevier Inc. All rights reserved.