A distributed cortical network for auditory sensory memory in humans
A distributed cortical network for auditory sensory memory in humans
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DOI：
10.1016/s0006-8993(98)00851-8
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发表时间：
1998-11-23
期刊：
影响因子：
2.9
通讯作者：
Knight, RT
中科院分区：
文献类型：
--
作者：
Alain, C;Woods, DL;Knight, RT
听觉感觉记忆是听觉感知中的关键第一阶段，它允许听众将传入的声学信息与先前的听觉事件的存储表示形式集成。在这里，我们使用对背外侧前额叶皮层，后侧关联皮层或海马的患者的行为和电生理处理进行了对感觉记忆的神经回路。我们使用了感觉记忆的自动组成部分的神经生理标记，不匹配负性（MMN）可以记录而不会公开注意。与对照组相比，颞顶患者的听觉歧视受损并降低了MMN振幅，这两种效应仅在与病变半球对侧的耳朵相对的刺激后发生。这表明听觉感觉记忆主要存储在与演示耳朵对侧的听觉皮层中。背侧前额叶损伤受损的性能受损，并降低了在任何耳朵中呈现的异常刺激引起的MMN，这意味着背外侧前额叶皮层对感觉记忆存储具有双侧促进作用。海马病变都不影响性能或电生理措施。结果提供了临时前额外的新皮质网络对听觉刺激的瞬时存储至关重要的证据。 （c）1998 Elsevier Science B.V.保留所有权利。
Auditory sensory memory is a critical first stage in auditory perception that permits Listeners to integrate incoming acoustic information with stored representations of preceding auditory events. Here, we investigated the neural circuits of sensory memory using behavioral and electrophysiological measures of auditory processing in patients with unilateral brain damage to dorsolateral prefrontal cortex, posterior association cortex, or the hippocampus. We used a neurophysiological marker of an automatic component of sensory memory, the mismatch negativity (MMN), which can be recorded without overt attention. In comparison with control subjects, temporal-parietal patients had impaired auditory discrimination and reduced MMN amplitudes with both effects evident only following stimuli presented in the ear contralateral to the lesioned hemisphere. This suggests that auditory sensory memories are predominantly stored in auditory cortex contralateral to the ear of presentation. Dorsolateral prefrontal damage impaired performance and reduced MMNs elicited by deviant stimuli presented in either ear, implying that dorsolateral prefrontal cortices have a bilateral facilitatory effect on sensory memory storage. Hippocampal lesions did not affect either performance or electrophysiological measures. The results provide evidence of a temporal-prefrontal neocortical network critical for the transient storage of auditory stimuli. (C) 1998 Elsevier Science B.V. All rights reserved.