Racial Disparity in Blood Pressure: is Vitamin D a Factor?
Racial Disparity in Blood Pressure: is Vitamin D a Factor?
复制标题
DOI：
10.1007/s11606-011-1707-8
复制
发表时间：
2011-10-01
影响因子：
5.7
通讯作者：
Franks, Peter
中科院分区：
文献类型：
--
作者：
Fiscella, Kevin;Winters, Paul;Franks, Peter
BACKGROUND: Higher prevalence of hypertension among African Americans is a key cause of racial disparity in cardiovascular morbidity and mortality. Explanations for the difference in prevalence are incomplete. Emerging data suggest that low vitamin D levels may contribute.OBJECTIVE: To assess the contribution of vitamin D to racial disparity in blood pressure.DESIGN: Cross-sectional analysis.PARTICIPANTS: Adult non-Hispanic Black and White participants from the National Health and Nutrition Examination Survey 2001-2006.MEASURES: We assessed Black-White differences in systolic blood pressure (SBP) controlling for conventional risk factors, and then additionally, for vitamin D (serum 25[OH]D).RESULTS: The sample included 1984 and 5156 Black and White participants ages 20 years and older. The mean age-sex adjusted Black-White SBP difference was 5.2 mm Hg. This difference was reduced to 4.0 mm Hg with additional adjustment for socio-demographic characteristics, health status, health care, health behaviors, and biomarkers; adding 25(OH)D reduced the race difference by 26% (95% CI 7-46%) to 2.9 mm Hg. This effect increased to 39% (95% CI 14-65%) when those on antihypertensive medications were excluded. Supplementary analyses that controlled for cardiovascular fitness, percent body fat, physical activity monitoring, skin type and social support yielded consistent results.CONCLUSION: In cross-sectional analyses, 25(OH)D explains one quarter of the Black-White disparity in SBP. Randomized controlled trials are required to determine whether vitamin D supplementation could reduce racial disparity in BP.
