Epidemiologic determinants of vaginal pH
Epidemiologic determinants of vaginal pH
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DOI：
10.1016/s0002-9378(99)70595-8
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发表时间：
1999-05-01
影响因子：
9.8
通讯作者：
Schiffman, M
中科院分区：
文献类型：
--
作者：
García-Closas, M;Herrero, R;Schiffman, M
目的：本研究旨在评估阴道pH值与宫颈癌相关因素之间的关系。研究设计：在以人群为基础的样本中，来自哥斯达黎加瓜纳卡斯特省的9161名妇女被分为两组，阴道pH值在参考范围（4.0-4.5）和阴道pH值升高（5.0-5.5）的妇女。比值比用于估计pH升高与其潜在决定因素之间的关系。结果：衰老与阴道pH值升高密切相关，从45岁左右开始并持续到老年。绝经使pH值升高的几率增加了1.7倍（优势比为1.7,95%可信区间为1.4-2.0）。结论：我们的数据表明阴道pH值与年龄和绝经状态密切相关，因此可能是与年龄相关的激素变化的标志。在感染人乳头瘤病毒的妇女中，pH值升高似乎与高级别上皮内瘤变的风险无关。
OBJECTIVES: This study was undertaken to evaluate the relationship between vaginal pH and factors related to cervical cancer.STUDY DESIGN: In a population-based sample of 9161 women from Guanacaste Province in Costa Pica women were categorized into 2 groups, those with vaginal pH in the reference range (4.0-4.5) and those with elevated vaginal pH (5.0-5.5). Odds ratios were used to estimate the relationship between elevated pH and its potential determinants.RESULTS: Aging was strongly associated with increasing vaginal pH, starting at around 45 years of age and continuing into old age. Menopause was responsible for an additional 1.7-fold increase in the odds of having an elevated pH (odds ratio 1.7, 95% confidence interval 1.4-2.0). Human papillomavirus infection and cervical intraepithelial neoplasia were not associated with changes in pH.CONCLUSIONS: Our data indicate that vaginal pH is strongly related to age and to menopausal status and thus could be a marker of age-related hormonal changes. Elevated pH does not appear to be associated with risk of high-grade intraepithelial neoplasia among women infected with human papillomavirus.