Regulation of cell function by extracellular matrix.
Regulation of cell function by extracellular matrix.
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细胞外基质调节细胞功能。
DOI：
10.1007/bf00861587
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kleinman,HK
中科院分区：
文献类型：
--
作者：
Schnaper,HW;Kleinman,HK
细胞外基质（ECM）为身体组织提供结构支持和粘附基质。我们对基质生物学的理解的最新进展表明，ECM在调节细胞行为方面也起着重要作用。基质蛋白引起细胞形状和运动的变化，结合生长因子，并促进细胞-细胞和细胞-基质相互作用。基质诱导的分化由多种刺激引起，包括：细胞上的张力、细胞因子或生长因子介导的刺激以及与基质糖蛋白的生物活性结构域的相互作用。由于这些信号是细胞行为的重要决定因素，因此细胞-基质相互作用的药理学操作可能为疾病治疗提供有价值的新方法。
The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a significant role in regulating the behavior of cells. Matrix proteins engender changes in cell shape and movement, bind growth factors, and facilitate cell-cell and cell-matrix interactions. Matrix-induced differentiation results from multiple stimuli that include: tensile forces on the cell, cytokine- or growth factor-mediated stimulation, and interaction with bioactive domains of matrix glycoproteins. Because these signals are important determinants of cell behavior, pharmacological manipulation of cell-matrix interactions may offer a valuable new approach to disease treatment.