Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?
Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring?
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DOI：
10.1136/thx.2006.067413
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发表时间：
2007-04-01
期刊：
影响因子：
10
通讯作者：
Smith, Jaclyn Ann
中科院分区：
文献类型：
--
作者：
Decalmer, Samantha Clare;Webster, Deborah;Smith, Jaclyn Ann
背景资料：咳嗽反射敏感性、咳嗽频率的主观估计和咳嗽相关生活质量已用于评估咳嗽和监测治疗反应。这些措施和客观咳嗽监测之间的关系仍不清楚，主观评估的有用性仍然questioned.Subjects：62例慢性咳嗽（39名妇女）进行了研究。患者的平均年龄为54.9（SD 12.2）岁，咳嗽的中位持续时间为5.5（范围1-30）years.Methods：咳嗽反射敏感性测试（C5，柠檬酸）进行了充分的门诊白天和夜间咳嗽记录前，所有患者。患者在每个记录期对其咳嗽频率和严重程度进行评分（视觉焦虑量表（VAS）和0-5分），并完成咳嗽相关生活质量问卷，莱斯特咳嗽问卷（LCQ）。手动计数动态咳嗽记录，并以每小时咳嗽秒数（cs/h）报告。结果：咳嗽时间中位数为11.36（范围1.06-46）cs/h，白天咳嗽频率中位数为15.59（范围2-74.8）cs/h，夜间咳嗽频率中位数为2.94（范围0-26.67）cs/h。白天咳嗽率与log 10 C5呈负相关（r =-0.452，p
Background: Cough reflex sensitivity, subjective estimates of cough frequency and cough-related quality of life have been used to assess cough and monitor treatment responses. The relationships between these measures and objective cough monitoring remain unclear and the usefulness of subjective assessments remains questionable.Subjects: 62 patients with chronic cough (39 women) were studied. Mean age of patients was 54.9 (SD 12.2) years, with a median duration of cough of 5.5 (range 1-30) years.Methods: Cough reflex sensitivity testing (C5; citric acid) was performed in all patients before fully ambulatory day-time and night-time cough recordings. Patients scored the frequency and severity of their cough ( Visual Analogue Scales ( VAS) and 0-5 score) for each recording period and completed a cough-related quality-of-life questionnaire, Leicester Cough Questionnaire (LCQ). Ambulatory cough recordings were manually counted and reported in terms of cough seconds per hour (cs/h). Cough rates were log(10) transformed for analysis.Results: The median time spent coughing was 11.36 (range 1.06-46) cs/h with median day rates of 15.59 (range 2-74.8) cs/h and median night rates of 2.94 (range 0-26.67) cs/h. An inverse relationship was seen between day cough rates and log10 C5 (r = -0.452, p