Inhaled and exhaled nitric oxide
Inhaled and exhaled nitric oxide
复制标题
吸入和呼出的一氧化氮
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
A. T. Dinh
中科院分区：
文献类型：
--
作者：
Bernard Thébaud;Jean;Jean;A. T. Dinh
摘要。吸入一氧化氮（NO）用于治疗肺动脉高压相关的各种心肺疾病。其基本原理是基于这样一个事实，即吸入一氧化氮只会扩张那些通气良好的肺单位的肺血管。结果，肺气体交换得到改善，肺血管阻力降低，肺血流量增加。吸入一氧化氮已成功应用于治疗新生儿持续性肺动脉高压，减少体外生命支持的需要。尽管肺动脉高压和血管反应性改变会导致成人和儿童急性呼吸窘迫综合征（ARDS）的深度低氧血症，但吸入一氧化氮对ARDS患者的益处仍有待确定。ARDS是肺对直接或间接损伤的复杂反应，导致肺血管收缩和各种炎症反应。最近的随机试验表明，吸入一氧化氮只会导致氧合的短暂改善。这种效应在ARDS的长期治疗中是否重要还有待确定。一氧化氮，在呼出的气体中测量，是监测上呼吸道和下呼吸道炎症的一种优雅且非侵入性的手段。在正常的上呼吸道中，呼出的大部分一氧化氮来自鼻窦。呼出一氧化氮在鼻变态反应中升高，在囊性纤维化、鼻息肉病和慢性鼻窦炎中降低。在哮喘气道中一氧化氮的产生也得到了很好的证实。然而，仍有几个问题需要解决，特别是评估测量技术的敏感性和特异性，以及评估内源性NO的支气管扩张作用。
Abstract. Inhaled nitric oxide (NO) is used to treat various cardiopulmonary disorders associated with pulmonary hypertension. The rationale is based on the fact that NO, given by inhalation, only dilates those pulmonary vessels that perfuse well-ventilated lung units. As a result, pulmonary gas exchange is improved while pulmonary vascular resistance is reduced and pulmonary blood flow is increased. Inhaled NO has been succesfully applied to treat persistent pulmonary hypertension of the newborn, reducing the need for extracorporeal life support. Although pulmonary hypertension and altered vasoreactivity contribute to profound hypoxaemia in adult and paediatric acute respiratory distress syndrome (ARDS), the benefit of inhaled NO still remains to be established in patients with ARDS. ARDS is a complex response of the lung to direct or indirect insults, leading to pulmonary vasoconstriction and various inflammatory responses. Recent randomized trials suggest that inhaled NO only causes a transient improvement in oxygenation. Whether this effect is important in the long-term management of ARDS remains to be established. NO, measured in the exhaled breath, is an elegant and non-invasive means to monitor inflammation of the upper and lower respiratory tract. In the normal upper airways, the bulk of exhaled NO originates from the paranasal sinuses. Exhaled NO is increased in nasal allergy and decreased in cystic fibrosis, nasal polyposis and chronic sinusitis. That NO production is increased in asthmatic airways is also well established. However, several questions still need to be addressed, in particular evaluation of the sensitivity and specificity of the measurement techniques, and assessment of the bronchodilator action of endogenous NO.
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一氧化氮减轻大鼠亚致死高氧引起的肺内皮损伤。
DOI：
10.1152/ajplung.1997.272.4.l631
发表时间：
1997
期刊：
The American journal of physiology.
影响因子：
--
作者：
McElroy,MC;Wiener-Kronish,JP;Miyazaki,H;Sawa,T;Modelska,K;Dobbs,LG;Pittet,JF
通讯作者：
Pittet,JF
影响因子：
56.9
作者：
WINK, DA;KASPRZAK, KS;KEEFER, LK
通讯作者：
KEEFER, LK
内源性一氧化氮抑制豚鼠吸入冷空气引起的支气管收缩：激肽的作用。
DOI：
10.1164/ajrccm.157.2.9704074
发表时间：
1998
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Yoshihara,S;Nadel,JA;Figini,M;Emanueli,C;Pradelles,P;Geppetti,P
通讯作者：
Geppetti,P
新生儿肺动脉高压新疗法对体外膜肺氧合使用和结果的影响。
DOI：
--
发表时间：
1997
期刊：
Journal of perinatology : official journal of the California Perinatal Association.
影响因子：
--
作者：
Kennaugh,JM;Kinsella,JP;Abman,SH;Hernandez,JA;Moreland,SG;Rosenberg,AA
通讯作者：
Rosenberg,AA
吸入一氧化氮可以逆转缺氧和酸中毒的新生羔羊的肺血管收缩。
影响因子：
20.1
作者：
RobertsJr,JD;Chen,TY;Kawai,N;Wain,J;Dupuy,P;Shimouchi,A;Bloch,K;Polaner,D;Zapol,WM
通讯作者：
Zapol,WM