Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
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DOI：
10.1016/j.schres.2007.03.015
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发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
Kahn, Rene S.
中科院分区：
文献类型：
--
作者：
Boks, Marco P. M.;de Vette, Marjolein H. T.;Kahn, Rene S.
Klinefelter患者中另一条x染色体的存在为研究该染色体对精神疾病的影响提供了机会。先前的研究报告了精神病人群体中过量的Klinefelter患者。我们报告了在Klinefelter患者样本中精神疾病的患病率增加，包括精神疾病，但未能找到证据表明父母来源的额外x染色体对精神表型有影响。然而，这些发现进一步支持了x染色体在一般精神疾病，特别是精神疾病易感性中的作用。(c) 2007 Elsevier B.V.版权所有
The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular. (c) 2007 Elsevier B.V. All rights reserved.