Polymorphisms of ABCG2 and its impact on clinical relevance
Polymorphisms of ABCG2 and its impact on clinical relevance
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ABCG2 的多态性及其对临床相关性的影响
DOI：
10.1016/j.bbrc.2018.06.157
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发表时间：
2018-09-05
影响因子：
3.1
通讯作者：
Shi, Zhi
中科院分区：
文献类型：
--
作者：
Zhang, Wenji;Sun, Shili;Shi, Zhi
人ABCG2是最重要的三磷酸腺苷结合盒(ABC)转运蛋白之一。这种蛋白质的功能是作为一种异源转运体，输送大的、疏水的、带正电荷或负电荷的分子、各种抗癌药物、荧光染料和正常食物中发现的不同有毒化合物。ABCG2中的SNPs可能会影响这些底物的吸收和分布，从而改变化合物或药物在大量人群中的积累、有效性和毒性。ABCG2的转运特性已被临床证实，ABCG2的表达与不同的疾病状态有关。我们综述了ABCG2的SNPs与痛风、急性髓系白血病、实体瘤和其他疾病的临床相关性。(C)2018 Elsevier Inc.保留所有权利。
Human ABCG2 is one of the most important ATP-binding cassette (ABC) transporters. This protein functions as a xenobiotic transporter of large, hydrophobic, positively or negatively charged molecules, a wide variety anticancer drugs, fluorescent dyes, and different toxic compounds found in normal food. SNPs in ABCG2 may affect absorption and distribution of these substrates, altering the accumulation, effectiveness and toxicity of compounds or drugs in large populations. Its transport properties have been implicated clinically and ABCG2 expression is linked with different disease states. We reviewed the SNPs of ABCG2 in clinical relevance about gout, acute myeloid leukemia, solid tumors, and other diseases. (C) 2018 Elsevier Inc. All rights reserved.