Exhaled leukotrienes and prostaglandins in COPD
Exhaled leukotrienes and prostaglandins in COPD
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DOI：
10.1136/thorax.58.7.585
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发表时间：
2003-07-01
期刊：
影响因子：
10
通讯作者：
Barnes, PJ
中科院分区：
文献类型：
--
作者：
Montuschi, P;Kharitonov, SA;Barnes, PJ
背景资料：类花生酸，包括白三烯（LT）和前列腺素（PG），在慢性阻塞性肺疾病（COPD）中的作用尚不确定。本研究的目的是调查呼出气冷凝液（EBC）中类花生酸是否可测量，这是一种收集气道分泌物的非侵入性方法，在稳定的轻度至中度COPD患者中，并显示其浓度与对照受试者相比可能存在的差异。方法：对15例健康戒烟者、20例未用过激素的COPD戒烟者、20例未用过激素的COPD患者、20例未用过激素的COPD患者进行EBC测定，以及25例既往吸烟并接受吸入性糖皮质激素治疗的COPD患者。结果：未经激素治疗组LTB_4和PGE（2）浓度升高（LTB_4：中位数100.6（范围73.5-145.0）pg/ml，P < 0.05），而未使用激素组LTB_4和PGE（2）浓度升高（LTB_4：中位数100.6（范围73.5-145.0）pg/ml，P < 0.05），P < 0.05）。
Background: The role of eicosanoids, including leukotrienes (LTs) and prostaglandins (PGs), in chronic obstructive pulmonary disease (COPD) is uncertain. The aim of this study was to investigate whether eicosanoids are measurable in exhaled breath condensate (EBC), a non-invasive method of collecting airway secretions, in patients with stable mild to moderate COPD, and to show possible differences in their concentrations compared with control subjects.Methods: LTB4, LTE4, PGE(2), PGD(2)-methoxime, PGF(2alpha), and thromboxane B-2 (TxB(2)) were measured in EBC in 15 healthy ex-smokers, 20 steroid naive patients with COPD who were ex-smokers, and in 25 patients with COPD who were ex-smokers and who were treated with inhaled corticosteroids. The study was of cross sectional design and all subjects were matched for age and smoking habit.Results: LTB4 and PGE(2) concentrations were increased in steroid naive (LTB4: median 100.6 (range 73.5-145.0) pg/ml, p