Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development.
Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development.
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阴道癌可能由子宫托和免疫功能低下引起：多种危险因素可能会影响阴道癌的发展。
DOI：
10.1111/jog.12958
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Fujii T
中科院分区：
文献类型：
--
作者：
Akino N;Wada-Hiraike O;Matsumoto Y;Arimoto T;Oda K;Kawana K;Osuga Y;Fujii T
原发性阴道癌是一种罕见疾病，仅占所有妇科恶性肿瘤的 1-2%。已知人乳头瘤病毒感染、免疫功能低下以及长期使用子宫托对阴道的慢性刺激会导致阴道癌的发生。我们经历过一例罕见的阴道癌病例，该病例是在使用阴道子宫托后发生的，同时患者服用口服泼尼松龙治疗特发性间质性肺炎。之前关于使用子宫托后发生阴道癌的报道大多是被忽视的子宫托，但在本例中，患者得到了妥善处理。我们怀疑她的免疫功能低下的状况以及子宫托的使用可能加速了阴道癌的发展。多种危险因素的存在可能与阴道癌的发病机制有关，因此在放置子宫托治疗子宫脱垂后需要进行适当的处理。
Primary cancer of the vagina is a rare entity, comprising only 1–2% of all gynecologic malignancies. Infection of human papillomavirus, immunocompromised condition, and chronic irritation of the vagina by prolonged pessary usage are known to contribute to the development of vaginal cancer. We experienced a rare case of vaginal cancer that occurred after usage of a vaginal pessary while the patient was prescribed with oral prednisolone for idiopathic interstitial pneumonia. Previous reports of vaginal cancer that occurred after pessary usage are mostly neglected pessaries, but in this case the patient was managed properly. We suspect that her immunocompromised condition, as well as her pessary usage, may have accelerated the development of vaginal cancer. The presence of multiple risk factors could be related to the pathogenesis of vaginal cancer, and therefore proper management is required after pessary insertion for uterine prolapse treatment.