SEROTONIN AND 5-HYDROXYINDOLEACETIC ACID LEVELS IN DISCRETE HYPOTHALAMIC AREAS OF THE RAT-BRAIN - RELATION TO CIRCULATING CORTICOSTERONE
SEROTONIN AND 5-HYDROXYINDOLEACETIC ACID LEVELS IN DISCRETE HYPOTHALAMIC AREAS OF THE RAT-BRAIN - RELATION TO CIRCULATING CORTICOSTERONE
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DOI：
10.1016/0304-3940(87)90687-2
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发表时间：
1987-08-18
影响因子：
2.5
通讯作者：
LEIBOWITZ, SF
中科院分区：
文献类型：
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作者：
JHANWARUNIYAL, M;RENNER, K;LEIBOWITZ, SF
我们研究了肾上腺切除术（ADX）和慢性皮质酮（CORT）替代对大鼠脑下丘脑离散区域5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）水平的影响。在ADX后7天，观察到室旁核（PVN）中5-HT（-25%）和5-HIAA（-28%）含量显著降低。ADX后在视前区（POM）中观察到5-HT水平的类似降低（-27%）。与此相反，5-HT和5-HIAA在视上核（SON）的水平显着升高，分别为82%和54%。在某些情况下，皮下CORT植入物（200 mg）替代治疗可有效预防ADX的这些影响。这些结果表明，垂体-肾上腺内分泌系统可能影响各种生理和行为功能，通过其对特定的下丘脑部位的肾上腺素能神经元的作用。
We examined the influence of adrenalectomy (ADX), and chronic corticosterone (CORT) replacement, on serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels in discrete hypothalamic areas of the rat brain. A significant decrease in 5-HT (-25%) and 5-HIAA (-28%) content was observed in the paraventricular nucleus (PVN) 7 days following ADX. A similar decrease in 5-HT levels (-27%) was observed in the preoptic area (POM) following ADX. In contrast, 5-HT and 5-HIAA levels in the supraoptic nucleus (SON) were significantly elevated by 82% and 54%, respectively. Replacement therapy with subcutaneous CORT implants (200 mg) was effective in preventing these effects of ADX in some cases. These findings suggest that the pituitary-adrenal endocrine system may influence various physiological and behavioral functions via its action on serotonergic neurons within specific hypothalamic sites.