The mechanism of agrin-induced acetylcholine receptor aggregation.
The mechanism of agrin-induced acetylcholine receptor aggregation.
复制标题
集聚蛋白诱导乙酰胆碱受体聚集的机制。
DOI：
10.1098/rstb.1991.0016
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Wallace,BG
中科院分区：
文献类型：
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作者：
Wallace,BG
聚集蛋白是从加利福尼亚电鳐（Torpedo californica）富含突触的电器官中分离的一种蛋白质，在培养物中诱导肌管上的特化形成，其类似于脊椎动物骨骼神经肌肉接头处的突触后装置。例如，特化包含乙酰胆碱受体和乙酰胆碱酯酶的聚集体。本文总结了在发育和再生的神经肌肉接头处突触后结构的形成是由运动轴突终末释放聚集蛋白触发的证据，并描述了最近的实验结果，这些实验表明聚集蛋白诱导的乙酰胆碱受体β亚基的酪氨酸磷酸化可能在受体聚集中起作用。
Agrin, a protein isolated from the synapse-rich electric organ ofTorpedo californica, induces the formation of specializations on myotubes in culture which resemble the post-synaptic apparatus at the vertebrate skeletal neuromuscular junction. For example, the specializations contain aggregates of acetylcholine receptors and acetylcholinesterase. This report summarizes the evidence that the formation of the postsynaptic apparatus at developing and regenerating neuromuscular junctions is triggered by the release of agrin from motor axon terminals and describes results of recent experiments which suggest that agrininduced tyrosine phosphorylation of the β subunit of the acetylcholine receptor may play a role in receptor aggregation.