Osteoprotegerin is Secreted Into the Coronary Circulation: A Possible Association with the Renin-Angiotensin System and Cardiac Hypertrophy
Osteoprotegerin is Secreted Into the Coronary Circulation: A Possible Association with the Renin-Angiotensin System and Cardiac Hypertrophy
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DOI：
10.1055/s-0034-1375611
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发表时间：
2014-07-01
影响因子：
2.2
通讯作者：
Kitamura, K.
中科院分区：
文献类型：
--
作者：
Koyama, S.;Tsuruda, T.;Kitamura, K.
循环中骨保护素（OPG）水平反映了一系列心血管疾病，但其来源仍有待确定。本研究探讨了OPG是否在冠状动脉循环中释放，以及它是否与心脏结构和功能相关。入选患者五十六例（年龄67 ± 10岁，男性57%，高血压73%，冠心病50%），血管造影后从左冠状动脉（CA）口和冠状静脉窦（CS）同时采集血样。CS中的OPG浓度高于CA（7.7 +/- 4.1 vs. 6.7 +/- 3.6 pmol/l，p < 0.001）。在接受血管紧张素转换酶抑制剂或血管紧张素II 1型受体阻滞剂（ACEI/ARB）处方的患者中，跨心脏OPG浓度显著降低（p = 0.019）。在未服用ACEI/ARB的患者亚组（n = 27）中，经心OPG水平与年龄（r = 0.396，p = 0.041）和相对左室壁厚度（r = 0.534，p = 0.004）呈正相关。在多变量线性回归分析中，相对壁厚仍然是经心OPG水平的自变量（p = 0.004）。此外，相对室壁厚度大于0.45的患者经心OPG显著增加（p = 0.021），但左心室质量指数增加（男性>= 116，女性>= 104，g/m2）或不增加（p = 0.627）无差异。这项研究表明，OPG被分泌到冠状动脉循环中，并与左心室向心性重塑/肥大相关，可能与肾素-血管紧张素系统相互作用。本文的支持信息可在http://www.thieme-connect.de/ejournals/toc/hmr上获得
The circulating osteoprotegerin (OPG) level reflects a series of cardiovascular diseases; however, the source(s) of circulating OPG remain(s) to be determined. This study explored whether OPG is released in the coronary circulation and whether it is associated with cardiac structure and function. Fifty-six patients (67 +/- 10 years old, male 57 %, hypertension 73 %, coronary artery disease 50 %) were enrolled, and blood samples were collected simultaneously from the orifice of the left coronary artery (CA) and the coronary sinus (CS) after angiography. The concentration of OPG was higher in the CS than in the CA (7.7 +/- 4.1 vs. 6.7 +/- 3.6 pmol/l, p < 0.001). The trans-cardiac OPG concentration was significantly (p = 0.019) decreased in patients who have been prescribed either an angiotensin converting enzyme inhibitor or an angiotensin II type 1 receptor blocker (ACEI/ARB). In patients sub-group who did not take an ACEI/ARB (n = 27), the trans-cardiac OPG level was positively correlated with age (r = 0.396, p = 0.041) and relative wall thickness of left ventricle (r = 0.534, p = 0.004). In multivariate linear regression analysis, relative wall thickness remained to be the independent variable for the trans-cardiac OPG level (p = 0.004). Moreover, trans-cardiac OPG was signifi cantly (p = 0.021) increased in patients with relative wall thickness greater than 0.45 but it did not differ if the left ventricular mass index was increased (>= 116 for males, or >= 104 for females, g/m(2)) or not (p = 0.627). This study suggests that OPG is secreted into the coronary circulation and is associated with concentric remodeling/hypertrophy of LV, possibly in interactions with the renin-angiotensin system. Supporting Information for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmr