Systemic absorption of insulin delivered topically to the rat eye.
Systemic absorption of insulin delivered topically to the rat eye.
复制标题
局部递送至大鼠眼睛的胰岛素的全身吸收。
DOI：
--
复制
发表时间：
1991
影响因子：
4.4
通讯作者：
W. Grizzle
中科院分区：
文献类型：
--
作者：
D. Pillion;J. Bartlett;E. Meezan;M. Yang;R. Crain;W. Grizzle
Insulin administration in eye drops containing 1% saponin caused a rapid and reproducible reduction in blood levels of D-glucose in anesthetized rats; insulin eye drops lacking saponin were ineffective. Systemic insulin absorption also was observed when Brij 78 or BL-9 was substituted for saponin in eye drops containing insulin. Nonanesthetized rats displayed lower initial D-glucose levels than anesthetized rats, and little hypoglycemic response to insulin eye drops could be observed, suggesting that counter-regulatory hormones could effectively counterbalance the influence of exogenous insulin on glycemic control. Streptozotocin-diabetic rats displayed elevated blood D-glucose values (greater than 400 mg/dl), and these values were decreased to 100-200 mg/dl after the administration of insulin in eye drop solutions containing saponin. The site of insulin absorption appears to be the nasolacrimal drainage system of the rat because administration of a solution containing insulin plus saponin directly into the punctum caused a rapid, significant decrease in blood D-glucose levels. The observation that insulin could be absorbed from the rat eye is consistent with the possibility that insulin eye drops containing an absorption-enhancing surfactant agent could be of potential benefit in the treatment of diabetes mellitus in humans.
结肠上皮细胞粘膜表面胰岛素受体的鉴定。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Pillion,DJ;Ganapathy,V;Leibach,FH
通讯作者：
Leibach,FH
影响因子：
56.9
作者：
SAFFRAN, M;KUMAR, GS;NECKERS, DC
通讯作者：
NECKERS, DC
胰岛素的结肠吸收：体外和体内评估。
DOI：
--
发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Atchison,JA;Grizzle,WE;Pillion,DJ
通讯作者：
Pillion,DJ