Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species
Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species
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Griseusins F 和 G，螺萘醌，来自锡矿尾矿衍生的嗜碱诺卡氏菌属物种
DOI：
10.1021/np3004936
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发表时间：
2012-11-01
影响因子：
5.1
通讯作者：
Wen, Meng-Liang
中科院分区：
文献类型：
--
作者：
Ding, Zhang-Gui;Zhao, Jiang-Yuan;Wen, Meng-Liang
灰霉菌F（1）和G（2）是从云南锡矿尾矿中分离到的一株嗜碱放线菌Nocardiapsis sp. YIM DT 266中分离到的两株2a-氢-8a-（2-氧丙基）-取代的螺环萘醌，具有一个未知的C-23聚酮骨架。通过光谱数据、X-射线晶体衍射、旋光度计算和圆二色光谱分析，用绝对立体化学方法确定了它们的完整结构。化合物1和2在体外对革兰氏阳性菌（包括耐甲氧西林金黄色葡萄球菌（MRSA））表现出强的细胞毒性（IC 50 0.37-0.82 μ M）和抗菌活性（MIC 0.80-1.65 μ g/mL）。
Griseusms F (1) and G (2), two 2a-hydro-8a-(2-oxopropyl)-substituted spiro-naphthoquinones with a previously undescribed C-23 polyketide skeleton, were isolated from a Yunnan tin mine tailings-derived alkalophilic actinomycete, Nocardiapsis sp. YIM DT266. Their complete structure assignments with the absolute stereochemistry were elucidated by spectroscopic data, X-ray crystal diffraction, calculation of optical rotation, and CD spectroscopic analysis. Compounds 1 and 2 exhibited strong cytotoxicity (IC50 0.37-0.82 mu M) and antibacterial activity (MIC 0.80-1.65 mu g/mL) against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) in vitro.