A description of clinician reported diagnosis of type 2 diabetes and other non-type 1 diabetes included in a large international multicentered pediatric diabetes registry (SWEET)
A description of clinician reported diagnosis of type 2 diabetes and other non-type 1 diabetes included in a large international multicentered pediatric diabetes registry (SWEET)
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DOI：
10.1111/pedi.12426
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发表时间：
2016-10-01
影响因子：
3.4
通讯作者：
Krisane, Iveta Dzivite
中科院分区：
文献类型：
--
作者：
Pacaud, Daniele;Schwandt, Anke;Krisane, Iveta Dzivite
背景资料：虽然1型糖尿病（T1D）仍然是发病年龄小于20岁的个体中最常见的糖尿病形式，但其他形式的糖尿病正日益被认识。目的：描述患有其他形式糖尿病的儿童人群（非1类）纳入多国SWEET（Better Control in Pediatric and Adolescent Diabetes S：Working to Create CEnTers of Reference）数据库。方法：输入SWEET数据库的病例由其医生根据ISPAD分类确定为T1D、2型糖尿病（T2D）和其他类型的糖尿病。其他类型的糖尿病提供了病因亚组。描述性分析制表发病年龄，性别，每日胰岛素剂量，血红蛋白A1C（A1C）为每种类型和亚型的糖尿病，并在可能的情况下，值进行了compared.Results：27 104例患者包括在本报告中，95.5%有T1D，1.3%T2D，和3.2%的其他形式的糖尿病。其他形式糖尿病的两种最常见病因是青年成熟期发病糖尿病（MODY）（n = 351）和囊性纤维化相关糖尿病（CFRD）（n = 193）。10%的其他形式的糖尿病的原因未知或未报告。与T1D相比，T2D和CFRD儿童的诊断年龄更大，胰岛素用量更少，A1C更低（均P < .0001）。结论：在SWEET纳入的中心，除1型糖尿病外的其他类型糖尿病仍然罕见，有时难以表征。SWEET中心之间共享这些罕见糖尿病的临床信息和结果有可能改善管理和结果。
Background: Although type 1 diabetes (T1D) remains the most frequent form of diabetes in individuals aged less than 20 years at onset, other forms of diabetes are being increasingly recognized.Objectives: To describe the population of children with other forms of diabetes (non-type 1) included in the multinational SWEET (Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) database for children with diabetes.Methods: Cases entered in the SWEET database are identified by their physician as T1D, type 2 diabetes (T2D) and other types of diabetes according to the ISPAD classification. Etiologic subgroups are provided for other types of diabetes. Descriptive analyses were tabulated for age at onset, gender, daily insulin doses, and hemoglobin A1c (A1C) for each type and subtype of diabetes and when possible, values were compared.Results: Of the 27 104 patients included in this report, 95.5% have T1D, 1.3% T2D, and 3.2% other forms of diabetes. The two most frequent etiologies for other forms of diabetes were maturity onset diabetes of the young (MODY) (n = 351) and cystic fibrosis-related diabetes (CFRD) (n = 193). The cause was unknown or unreported in 10% of other forms of diabetes. Compared with T1D, children with T2D and CFRD were diagnosed at an older age, took less insulin and had lower A1C (all P < .0001).Conclusion: In centers included in SWEET, forms of diabetes other than type 1 remain rare and at times difficult to characterize. Sharing clinical information and outcome between SWEET centers on those rare forms of diabetes has the potential to improve management and outcome.