ADAPTIVE MULTIVARIABLE DRUG DELIVERY - CONTROL OF ARTERIAL-PRESSURE AND CARDIAC-OUTPUT IN ANESTHETIZED DOGS
ADAPTIVE MULTIVARIABLE DRUG DELIVERY - CONTROL OF ARTERIAL-PRESSURE AND CARDIAC-OUTPUT IN ANESTHETIZED DOGS
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DOI：
10.1109/tbme.1987.326093
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发表时间：
1987-08-01
影响因子：
4.6
通讯作者：
CHIZECK, HJ
中科院分区：
文献类型：
--
作者：
VOSS, GI;KATONA, PG;CHIZECK, HJ
实现并测试了一种用于控制多输入/多输出生理系统的自适应算法（CAMAC，控制超前移动平均控制器）。该算法是一种自调谐控制器，它在等于或大于系统死区时间的时间间隔内，根据输出和期望输出之间的期望差来确定输入。该算法通过计算机控制同时输注硝普钠和多巴酚丁胺来同时控制麻醉犬的平均动脉压和心输出量。结果证明了CAMAC用于多变量药物递送的可行性，但它们表明在临床应用之前需要进一步的工作。
An adaptive algorithm (CAMAC, control advance moving average controller) to control multiinput/multioutput physiological systems has been implemented and tested. The algorithm is a self-tuning controller that determines the input on the basis of the expected difference between the output and desired output at a time interval equal to or greater than the system dead time. The algorithm was used to simultaneously control mean arterial pressure and cardiac output in anesthetized dogs by the simultaneous computer-controlled infusion of sodium nitroprusside and dobutamine. The results demonstrate the feasibility of using CAMAC for multivariable drug delivery, but they indicate the need for further work before clinical applications are attempted.