Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth
Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth
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DOI：
10.1159/000217979
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发表时间：
1996-05-01
期刊：
影响因子：
--
通讯作者：
Hosokawa, M
中科院分区：
文献类型：
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作者：
Shibata, T;Kawano, T;Hosokawa, M
为探讨表皮生长因子（EGF）对人口腔鳞癌细胞侵袭能力的影响，采用噬菌动力学追踪法和酶谱法研究了3株人口腔鳞癌细胞系EGF对人口腔鳞癌细胞侵袭能力的影响。发现EGF（1-100 ng/ml）以浓度依赖性方式抑制所有三种细胞系的生长但增强随机运动性。EGF可剂量依赖性地诱导同一细胞产生尿激酶型纤溶酶原激活物和M（r）92 kD基质金属蛋白酶，提示EGF可促进人鳞状细胞癌的侵袭和转移。
In order to ascertain the effects of epidermal growth factor (EGF) on human cancer invasion abilities, three cell lines of human oral squamous cell carcinoma were studied using a phagokinetic track assay and zymography. EGF(1-100 ng/ml) was found to inhibit the growth but enhance the random motility of all three cell lines in a concentration-dependent fashion. Exposure to EGF, dose-dependently, led to an increased production of urokinase-type plasminogen activator and M(r) 92 kD matrix metalloproteinase by the same cells, These results strongly suggest that EGF may promote human squamous cell carcinoma invasion and metastasis.