Brucellosis in Nepal - A Potential Threat to Public Health Professionals.
Brucellosis in Nepal - A Potential Threat to Public Health Professionals.
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DOI：
10.12865/chsj.42.04.10
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发表时间：
2016-10-01
影响因子：
--
通讯作者：
Acharya, K P
中科院分区：
文献类型：
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作者：
Acharya, K P
布鲁氏菌病是一种影响人类和动物的突出的人畜共患疾病，由于缺乏适当的诊断和治疗，在尼泊尔等第三世界国家仍然很危险。目前，布鲁氏菌病构成了一个公共卫生问题，其在整个牲畜群中的发病率可能给牧民和卫生专业人员带来巨大的经济和健康负担。此外，与动物密切接触、畜牧业不良和不卫生的饲养习惯等因素可加剧布鲁氏菌和相关人畜共患病病原体的传播。在尼泊尔，已经报告了牛甚至人类布鲁氏菌病的严重病例，尽管这一专题尚未得到广泛审查。本文对尼泊尔和其他国家关于人和动物布鲁氏菌病的文献进行了评价，重点是布鲁氏菌病暴发对公共卫生专业人员的影响。在此，我们总结了疾病的现状，感染机制，发病机制，人畜共患病的潜力，诊断进展，治疗方案，以及在管理人类布鲁氏菌病在欠发达国家，如尼泊尔，可以采取的预防措施。
Brucellosis is a prominent zoonotic disease affecting humans and animals which with the lack of proper diagnosis and treatment remains dangerous in third world countries like Nepal. Currently, Brucellosis poses a public health concern, whose incidences among entire herds of animals can present substantial economic and health burdens for herders and health professionals. Additionally, factors such as close contact with animals, poor animal husbandry, and unhygienic feeding habits can exacerbate the spread of Brucella and related zoonotic agents. In Nepal, serious cases of bovine and even human brucellosis have been reported, although the topic is yet to be extensively reviewed. This paper evaluates the literatures on human and animal brucellosis in Nepal and other countries, with an emphasis on the impact of Brucella outbreaks on public health professionals. Herein, we summarize the current status of the disease, the mechanism of infection, pathogenesis, zoonotic potential, diagnostic advances, treatment regimens, and the preventive measures that can be adopted in managing human brucellosis in under-developed countries such as Nepal.