An Air Filter Intervention Study of Endothelial Function among Healthy Adults in a Woodsmoke-impacted Community
An Air Filter Intervention Study of Endothelial Function among Healthy Adults in a Woodsmoke-impacted Community
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DOI：
10.1164/rccm.201010-1572oc
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发表时间：
2011-05-01
影响因子：
24.7
通讯作者：
Brauer, Michael
中科院分区：
文献类型：
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作者：
Allen, Ryan W.;Carlsten, Chris;Brauer, Michael
理由：空气颗粒物污染与心血管疾病发病率相关。一种假设的机制涉及氧化应激、全身炎症和内皮功能障碍。目的：评估干预措施对受木烟影响的社区健康成年人的颗粒暴露和内皮功能的影响。我们还研究了氧化应激和炎症与减少暴露量相关的潜在作用。方法：在一项随机交叉干预研究中，使用便携式空气过滤器对 45 名健康成年人进行了连续 7 天暴露于过滤和未过滤空气的研究。测量和主要结果：通过外周动脉张力测定法测量反应性充血指数，作为内皮功能的指标，并且 对炎症标志物（C 反应蛋白、白细胞介素 6 和带状细胞）和脂质过氧化（丙二醛和 8-异前列腺素 F-2 α）进行定量。空气过滤器可将室内细颗粒浓度降低 60%。过滤与反应性充血指数增加 9.4%（95% 置信区间，0.9-18%）和 C 反应蛋白减少 32.6%（4.4-60.9%）相关。颗粒物和木烟示踪剂左旋葡聚糖的减少与条带细胞计数的减少有关。有限的证据表明，对男性、超重参与者、年轻参与者和燃木房屋居民的内皮功能和全身炎症水平有更明显的影响。未发现氧化应激标记物存在关联。结论：空气过滤与改善内皮功能和降低炎症生物标记物浓度相关，但与氧化应激标记物无关。我们的结果支持这样的假设：全身炎症和内皮功能受损（心血管发病的两个预测因子）可以通过降低室内颗粒浓度产生有利影响。
Rationale: Particulate air pollution is associated with cardiovascular morbidity. One hypothesized mechanism involves oxidative stress, systemic inflammation, and endothelial dysfunction.Objectives: To assess an intervention's impact on particle exposures and endothelial function among healthy adults in a woodsmoke-impacted community. We also investigated the underlying role of oxidative stress and inflammation in relation to exposure reductions.Methods: Portable air filters were used in a randomized crossover intervention study of 45 healthy adults exposed to consecutive 7-day periods of filtered and nonfiltered air.Measurements and Main Results: Reactive hyperemia index was measured as an indicator of endothelial function via peripheral artery tonometry, and markers of inflammation (C-reactive protein, interleukin-6, and band cells) and lipid peroxidation (malondialdehyde and 8-iso-prostaglandin F-2 alpha) were quantified. Air filters reduced indoor fine particle concentrations by 60%. Filtration was associated with a 9.4% (95% confidence interval, 0.9-18%) increase in reactive hyperemia index and a 32.6% (4.4-60.9%) decrease in C-reactive protein. Decreases in particulate matter and the woodsmoke tracer levoglucosan were associated with reduced band cell counts. There was limited evidence of more pronounced effects on endothelial function and level of systemic inflammation among males, overweight participants, younger participants, and residents of wood-burning homes. No associations were noted for oxidative stress markers.Conclusions: Air filtration was associated with improved endothelial function and decreased concentrations of inflammatory biomarkers but not markers of oxidative stress. Our results support the hypothesis that systemic inflammation and impaired endothelial function, both predictors of cardiovascular morbidity, can be favorably influenced by reducing indoor particle concentrations.