KINETIC DIFFERENCES IN UNRESPONSIVENESS OF THYMUS AND BONE MARROW CELLS
KINETIC DIFFERENCES IN UNRESPONSIVENESS OF THYMUS AND BONE MARROW CELLS
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DOI：
10.1126/science.171.3973.813
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
WEIGLE, WO
中科院分区：
文献类型：
--
作者：
CHILLER, JM;HABICHT, GS;WEIGLE, WO
成年小鼠的胸腺和骨髓细胞都可以特异性地对人丙种球蛋白无反应，但每种细胞群显示出诱导和自发丧失无反应状态的不同动力学模式。这些动力学似乎在骨髓细胞中比在胸腺细胞中慢得多。此外，诱导骨髓细胞无反应性所需的解聚人丙种球蛋白剂量远大于诱导胸腺细胞无反应性所需的剂量。显然，仅一种细胞类型的无反应性就足以使完整动物表现出耐受状态。
Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction and spontaneous loss of the unresponsive state. These kinetics appear to be much slower in the bone marrow cells than in the thymus cells. In addition, the dose of deaggregated human gamma globulin needed to induce unresponsiveness in bone marrow cells is much greater than that needed to induce unresponsiveness in thymus cells. Apparently, unresponsiveness in only one cell type is sufficient for the tolerant state to be exhibited by the intact animal.