Individual and synergistic effects of sniffing frequency and flow rate on olfactory bulb activity
Individual and synergistic effects of sniffing frequency and flow rate on olfactory bulb activity
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DOI：
10.1152/jn.00672.2011
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发表时间：
2011-12-01
影响因子：
2.5
通讯作者：
Buonviso, Nathalie
中科院分区：
文献类型：
--
作者：
Courtiol, Emmanuelle;Hegoburu, Chloe;Buonviso, Nathalie
[10]李国雄，李国雄.嗅频与嗅流率对嗅球活动之个别与协同效应。J Neurophysiol 106：2813-2824，2011.首次发表于2011年9月7日; doi：10.1152/jn.00672.2011.-更快或更强的嗅探对嗅觉系统重要吗？气味分子是通过嗅来捕捉的。嗅闻的特征限制了对嗅觉结构的输入的时间性和强度。在这种情况下，很明显，吸气频率和流速的变化对嗅觉结构的激活有重大影响。然而，频率和流速如何单独或协同影响球输出的问题尚未得到回答。我们已经使用多种实验方法解决了这个问题。在双气管切开麻醉大鼠，我们记录了球局部场电位（LFP）和二尖瓣/簇状细胞的活动时，采样流速和频率是独立控制的。我们发现，采样频率和流速之间的权衡可以保持嗅球采样相关的节律性，只有流速的增加可以诱导更快的，气味诱发的反应。在清醒大鼠中记录LFP和嗅闻。我们发现，在高频嗅探期间，与采样相关的节律性得到了维持。此外，我们观察到，频率和流速之间的协变，这是必要的权衡中看到的麻醉制剂，也发生在清醒的动物。我们的研究表明，采样频率和流量可以单独或协同作用于延髓输出，以塑造神经元的信息。该系统可能会利用这种灵活性来调整嗅探策略以适应动物行为。我们的研究提供了额外的支持的想法，嗅探和嗅觉功能在一个综合的方式。
Courtiol E, Hegoburu C, Litaudon P, Garcia S, Fourcaud-Trocme N, Buonviso N. Individual and synergistic effects of sniffing frequency and flow rate on olfactory bulb activity. J Neurophysiol 106: 2813-2824, 2011. First published September 7, 2011; doi: 10.1152/jn.00672.2011.-Is faster or stronger sniffing important for the olfactory system? Odorant molecules are captured by sniffing. The features of sniffing constrain both the temporality and intensity of the input to the olfactory structures. In this context, it is clear that variations in both the sniff frequency and flow rate have a major impact on the activation of olfactory structures. However, the question of how frequency and flow rate individually or synergistically impact bulbar output has not been answered. We have addressed this question using multiple experimental approaches. In double-tracheotomized, anesthetized rats, we recorded both the bulbar local field potential (LFP) and mitral/tufted cells' activities when the sampling flow rate and frequency were controlled independently. We found that a tradeoff between the sampling frequency and the flow rate could maintain olfactory bulb sampling-related rhythmicity and that only an increase in flow rate could induce a faster, odor-evoked response. LFP and sniffing were recorded in awake rats. We found that sampling-related rhythmicity was maintained during high-frequency sniffing. Furthermore, we observed that the covariation between the frequency and flow rate, which was necessary for the tradeoff seen in the anesthetized preparations, also occurred in awake animals. Our study shows that the sampling frequency and flow rate can act either independently or synergistically on bulbar output to shape the neuronal message. The system likely takes advantage of this flexibility to adapt sniffing strategies to animal behavior. Our study provides additional support for the idea that sniffing and olfaction function in an integrated manner.