Direct and mediated associations between P300 amplitude in childhood and substance use disorders outcome in young adulthood
Direct and mediated associations between P300 amplitude in childhood and substance use disorders outcome in young adulthood
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DOI：
10.1016/j.biopsych.2004.09.028
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发表时间：
2005-01-01
影响因子：
10.6
通讯作者：
Tarter, RE
中科院分区：
文献类型：
--
作者：
Habeych, ME;Charles, PJ;Tarter, RE
背景：在物质使用障碍（SUD）高危青年中，经常记录到P300波振幅衰减。本研究有两个目的：1）确定儿童晚期P300振幅是否是19岁时SUD结果的预测因子; 2）评估神经行为去抑制（ND）是否介导了这种关联。男孩（10-12岁）通过先证者的生父招募，其具有SUD的终生DSM-III-R诊断（N = 67）或无成人精神障碍（N = 94）。在听觉oddball任务期间记录P300振幅。神经行为去抑制进行了评估执行认知功能，行为控制不足，情绪失调的测试。使用多重和逻辑回归评估这种关系。结果：P300振幅可以显着预测19岁之前的物质使用障碍（比值比[OR] = .958; 95%置信区间[CI] = .918-.999; Wald chi（2）= 3.992; df = 1; p = .045）和ND评分（OR = 1.060; 95% CI = 1.023-1.098; Wald chi（2）10.267; df = 1; p = .0014），在10至12岁时测量。P300振幅也与ND严重程度显著相关（β =-0.217; t = -2.412; df = 6，160; p = 0.017）。19岁时死于SUD的儿童P300波幅较低。结论：ND介导了儿童期P300波幅衰减与19岁时SUD的关系，但P300波幅不是SUD的特异性儿童期标志。
Background: Attenuated amplitude of the P300 wave has been frequently documented in youths at high risk for substance use disorders (SUDs). This investigation bad two aims: 1) determine whether P300 amplitude in late childhood is a predictor of SUD outcome by age 19; and 2) evaluate whether neurobehavior disinhibition (ND) mediates this association.Methods: Boys (aged 10-12) were recruited through proband biological fathers with either a lifetime DSM-III-R diagnosis of SUD (N = 67) or no adult psychiatric disorder (N = 94). P300 amplitude was recorded during an auditory oddball task. Neurobehavior disinhibition was evaluated using tests of executive cognitive function, behavior undercontrol, and emotion dysregulation. The relationship is assessed using multiple and logistic regressions.Results: Substance use disorder by age 19 was significantly predicted by P300 amplitude (odds ratio [OR] = .958; 95% confidence interval [CI] = .918-.999; Wald chi(2) = 3.992; df = 1; p = .045) and ND score (OR = 1.060; 95% CI = 1.023-1.098; Wald chi(2) 10.267; df = 1; p = .0014) measured at age 10 to 12. P300 amplitude also significantly correlated with ND severity (beta = -.217; t = -2.412; df = 6,160; p = .017). Low P300 amplitudes were observed in children who succumbed to SUD by age 19.Conclusions: These results indicate that ND mediates the association between attenuated P300 amplitude in childhood and SUD at age 19; however, P300 amplitude is not a specific childhood marker of SUD.