Adult patient-specific CT organ dose estimations using automated segmentations and Monte Carlo simulations.
Adult patient-specific CT organ dose estimations using automated segmentations and Monte Carlo simulations.
复制标题
使用自动分割和蒙特卡罗模拟进行成人患者特定 CT 器官剂量估计。
DOI：
10.1088/2057-1976/ab98e6
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发表时间：
2020
影响因子：
1.4
通讯作者：
Summers,RonaldM
中科院分区：
文献类型：
--
作者：
Lee,Choonsik;Liu,Jiamin;Griffin,Keith;Folio,Les;Summers,RonaldM
我们的目的是确定使用腹部器官专用自动分割技术结合临床 CT 扫描仪的蒙特卡罗模拟来计算腹部计算机断层扫描 (CT) 检查的患者特定器官剂量的可行性。我们对 10 名成年患者的 5 个主要腹部器官（左右肾、胰腺、脾脏和肝脏）进行了自动分割，并计算了每位患者的器官特异性剂量。我们观察到 10 名患者的器官质量存在显着变异（变异系数高达 32%），比 ICRP 参考成年男性和女性的参考器官质量大或小两倍。将每个 CTDI 体积的患者特定器官剂量与 ICRP 参考体模的剂量进行比较，证实基于参考体模的剂量报告程序无法捕获患者间的剂量变异性，并且剂量测定误差可能高达近 40%。我们演示了一种用于患者特定器官剂量计算的自动化方法，每个患者大约需要 45 分钟。当自动分割方法扩展到更多器官并采用更快的蒙特卡罗计算技术时，我们的方法应该可用于器官水平的患者特异性剂量监测以及CT患者健康风险的流行病学调查。
We aimed to determine feasibility in calculating patient-specific organ doses for abdominal computed tomography (CT) exams using an automated segmentation technique dedicated to abdominal organs combined with Monte Carlo simulation of a clinical CT scanner. We conducted the automated segmentation of five major abdominal organs (left and right kidneys, pancreas, spleen, and liver) for ten adult patients and calculated organ-specific doses for each patient. We observed significant variability (Coefficient of Variation up to 32%) in organ mass across the ten patients, which was up to two-fold greater or smaller than the reference organ mass for the ICRP reference adult male and female. Comparison of patient-specific organ dose per CTDI vol with those from the ICRP reference phantoms confirmed that reference phantom-based dose reporting programs cannot capture inter-patient dose variability, and dosimetric errors can go up to nearly 40%. We demonstrated an automated method for patient-specific organ dose calculations, which took about 45 min per patient. When the automatic segmentation method is extended to more organs and faster Monte Carlo calculation technique is employed, our method should be useful for patient-specific dose monitoring at the organ level and for epidemiological investigations of health risks in CT patients.