Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review
Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review
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DOI：
10.1034/j.1600-051x.29.s3.1.x
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发表时间：
2002-01-01
影响因子：
6.7
通讯作者：
Madianos, PN
中科院分区：
文献类型：
--
作者：
Mombelli, A;Casagni, F;Madianos, PN
目的：本研究的目的是确定在何种程度上牙周病原体的存在或不存在可以区分慢性和侵袭性periodontitis.Material和Methods：一个系统的横向和纵向的研究提供的微生物学数据都从慢性牙周炎（ChP）和侵袭性牙周炎（AgP）患者在受试者的水平。采用严格的入选标准。结果：共检出放线杆菌（AA）、牙龈卟啉单胞菌（PG）、中间普雷沃菌（PI）、类杆菌（BF）和直弯杆菌（CR）5种微生物。在7篇论文中，可以分析是否存在PG。从6项研究中获得了PI的受试者特定数据。两项研究可用于是否存在BF，两项研究可用于CR。假设AgP或ChP的临床诊断是试验试图检测的真实状态，则针对每个选定研究单独计算每个微生物学试验的灵敏度和特异性。认为AgP是关注的条件，认为ChP等同于“非AgP”。使用这些数据构建受试者操作特征（ROC）图。ROC图表明，所有的测试参数，以确定受试者与AgP有限的歧视能力。一项额外的评估表明，AA的高白细胞毒性变体与侵袭性牙周炎患者唯一相关。然而，在一个高比例的诊断与AgP的患者的存在下，这种变异无法检测到。结论：AA，PG，PI，BF或CR的存在或不存在不能区分与AgP从那些与ChP的受试者。
Objectives: The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis.Material and Methods: A systematic review of cross sectional and longitudinal studies providing microbiological data both from patients with chronic periodontitis (ChP) and aggressive periodontitis (AgP) at a subject level. Strict inclusion criteria were applied. The presence or absence of five microorganisms was selected as primary study parameters: Actinobacillus actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Prevotella intermedia (PI), Bacteroides forsythus (BF), and Campylobacter rectus (CR).Results: The presence or absence of AA could be evaluated in 11 papers. In seven papers the presence or absence of PG could be analysed. Subject specific data on PI were available from six studies. Two studies could be used regarding the presence or absence of BF, and two regarding CR. Sensitivity and specificity of every microbiological test were individually calculated for each selected study, assuming that the clinical diagnosis of AgP or ChP was the true status the tests attempted to detect. AgP was considered to be the condition of interest and ChP was considered equivalent to 'non-AgP'. Receiver Operator Characteristic (ROC) diagrams were constructed using these data. ROC diagrams indicated the limited discriminatory ability of all of the test parameters to identify subjects with AgP. An additional assessment showed that the highly leukotoxic variant of AA was uniquely associated with patients suffering from aggressive periodontitis. However, in a high proportion of patients diagnosed with AgP the presence of this variant could not be detected.Conclusion: The presence or absence of AA, PG, PI, BF or CR could not discriminate between subjects with AgP from those with ChP.