β-catenin, a novel prognostic marker for breast cancer:: Its roles in cyclin D1 expression and cancer progression
β-catenin, a novel prognostic marker for breast cancer:: Its roles in cyclin D1 expression and cancer progression
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DOI：
10.1073/pnas.060025397
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发表时间：
2000-04-11
影响因子：
11.1
通讯作者：
Hung, MC
中科院分区：
文献类型：
--
作者：
Lin, SY;Xia, WY;Hung, MC
当β -连环蛋白易位到细胞核，与T细胞因子或淋巴细胞增强因子家族成员结合，并激活其靶基因时，可作为癌基因发挥作用。在这项研究中，我们证明了cyclin D1是β -连环蛋白在乳腺癌细胞中的靶标之一。在8种体外乳腺细胞系和123例患者样本中，β -连环蛋白的转激活与cyclin D1的表达显著相关。更重要的是，我们发现高β -catenin活性与患者的不良预后显著相关，是乳腺癌的一个强大且独立的预后因素。因此，我们的研究表明β -连环蛋白可能参与乳腺癌的形成和/或进展，并可能作为乳腺癌治疗的靶点。
beta-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In this study, we demonstrate that cyclin D1 is one of the targets of beta-catenin in breast cancer cells. Transactivation of beta-catenin correlated significantly with cyclin D1 expression both in eight breast cell lines in vitro and in 123 patient samples. More importantly, we found that high beta-catenin activity significantly correlated with poor prognosis of the patients and was a strong and independent prognostic factor in breast cancer. Our studies, therefore, indicated that beta-catenin can be involved in breast cancer formation and/or progression and may serve as a target for breast cancer therapy.