Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
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DOI：
10.5012/bkcs.2010.31.03.588
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发表时间：
2010-03-20
影响因子：
1.7
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Kimura, Yasuaki;Yamatsugu, Kenzo;Shibasaki, Masakatsu
通过对磷酸奥司他韦（达菲）原合成路线的修饰，合成了两种树脂偶联的达菲类似物。制备的树脂与流感病毒神经氨酸酶结合，这是达菲的主要靶点。这些树脂将有助于分离和鉴定可能与达菲相互作用的内源性脊椎动物蛋白，这可能与一些接受达菲治疗的流感患者罕见的异常行为有关。
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.