Antibacterial action of 4,4'-bipyrazolyl-based silver(I) coordination polymers embedded in PE disks.
Antibacterial action of 4,4'-bipyrazolyl-based silver(I) coordination polymers embedded in PE disks.
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DOI：
10.1021/ic3011635
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发表时间：
2012-08
影响因子：
4.6
通讯作者：
A. Tǎbǎcaru;C. Pettinari;F. Marchetti;Corrado Di Nicola;K. V. Domasevitch;S. Galli;N. Masciocchi;S. Scuri;I. Grappasonni;M. Cocchioni
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文献类型：
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作者：
A. Tǎbǎcaru;C. Pettinari;F. Marchetti;Corrado Di Nicola;K. V. Domasevitch;S. Galli;N. Masciocchi;S. Scuri;I. Grappasonni;M. Cocchioni
以阴离子或中性形式将刚性间隔剂4,4'-联吡唑（H(2)BPZ）与不同的银(I)盐偶联，可以分离出新的配位聚合物[Ag(2)(BPZ)](1)和[Ag(H(2)BPZ)(X)] (X = NO(3), 2；克罗(4)3;男朋友(4)4;PF (6), 5;CH (3) (3), 6;CF(3)、SO(3)、7)，通过红外光谱、发射光谱、热分析和x射线粉末衍射对其进行了表征。1的晶体结构由二维层组成，其中包含由外四齿双吡唑基团桥接的一维银(I)离子链。[Ag(H(2)BPZ)(X)] 2-7的晶体结构具有[Ag(H(2)BPZ)]的一维化学对称链，金属中心由外双齿联吡唑基间隔剂桥接。相邻链之间的接触是由反离子介导的，通过涉及Ag(I)离子和吡唑基N-H基团的非键相互作用。热重分析揭示了这些材料良好的热稳定性，在200-300°C范围内分解。在室温紫外照射下，所有物种都在520 ~ 522 nm范围内发出黄绿色荧光。当将1、2和4-7包埋在聚乙烯磁盘中时，它们作为局部抗菌剂对大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌的悬浮液显示出活性：在24小时内，这三种细菌菌株完全减少，仅在2小时内，金黄色葡萄球菌的减少量就达到约90%。接触药敏试验也表达了杀菌作用。
Coupling the rigid spacer 4,4'-bipyrazole (H(2)BPZ), in its anionic or neutral form, to different silver(I) salts allowed isolation of the novel coordination polymers [Ag(2)(BPZ)] (1) and [Ag(H(2)BPZ)(X)] (X = NO(3), 2; ClO(4), 3; BF(4), 4; PF(6), 5; CH(3)SO(3), 6; CF(3)SO(3), 7), which were fully characterized by infrared and emission spectroscopies, thermal analysis, and X-ray powder diffraction. The crystal structure of 1 consists of 2-D layers containing 1-D chains of Ag(I) ions bridged by exo-tetradentate bipyrazolato moieties. The crystal structures of the [Ag(H(2)BPZ)(X)] species 2-7 feature 1-D chains of [Ag(H(2)BPZ)] stoichiometry, along which the metal centers are bridged by exo-bidentate bipyrazolyl spacers. Contacts among adjacent chains are mediated by the counterions through nonbonding interactions involving the Ag(I) ions and the pyrazolyl N-H groups. Thermogravimetric analyses disclosed the good thermal stability of these materials, decomposing in the range 200-300 °C. Under UV irradiation at room temperature, all the species showed a yellow-green emission centered in the range 520-522 nm. When embedded into polyethylene disks, 1, 2, and 4-7 demonstrated their activity as topical antibacterial agents against suspensions of E. coli, P. aeruginosa, and S. aureus: complete reduction of the three bacterial strains was achieved in 24 h, reduction of S. aureus reaching ca. 90% in only 2 h. Biocidal action was expressed also by contact susceptibility tests.