The level of erythrocyte aldose reductase is associated with the severity of diabetic retinopathy
The level of erythrocyte aldose reductase is associated with the severity of diabetic retinopathy
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DOI：
10.1016/s0168-8227(97)00079-x
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发表时间：
1997-09-01
影响因子：
5.1
通讯作者：
Saito, T
中科院分区：
文献类型：
--
作者：
Nishimura, C;Hotta, Y;Saito, T
为了检查红细胞醛糖还原酶水平是否是糖尿病视网膜病变严重程度的危险因素，通过双位点酶联免疫吸附测定法测量了 97 名非胰岛素依赖型糖尿病 (NIDDM) 患者的酶水平。根据眼底照相和生物显微镜检查的结果，对10年以上的NIDDM患者视网膜病变的严重程度进行分类。活动性增殖性视网膜病变患者的红细胞醛糖还原酶水平显着高于非增殖性或静止性增殖性视网膜病变患者。多变量logistic回归分析表明，红细胞醛糖还原酶水平是活动性增殖性视网膜病变的独立危险因素（比值比，1.28；95%置信区间，1.01-1.61）。结果提示NIDDM患者红细胞醛糖还原酶水平高可能影响糖尿病视网膜病变的预后。酶水平高的患者在视网膜并发症的治疗中需要密切随访。 (C) 1997 爱思唯尔科学爱尔兰有限公司
To examine whether the level of erythrocyte aldose reductase is a risk factor for the severity of diabetic retinopathy, the enzyme level in 97 non-insulin-dependent diabetes mellitus (NIDDM) patients was measured by the two-site enzyme-linked immunosorbent assay. Based on the results of fundus photography and biomicroscopy, the severity of retinopathy was classified among NIDDM patients of more than 10 years. The level of erythrocyte aldose reductase was significantly higher in the patients with active proliferative retinopathy than in those with nonproliferative or quiescent proliferative retinopathy. Multivariate logistic regression analysis demonstrated that the level of erythrocyte aldose reductase was an independent risk factor for active proliferative retinopathy (odds ratio, 1.28; 95% confidence interval, 1.01-1.61). The results suggest that a high level of erythrocyte aldose reductase in NIDDM patients may affect the prognosis of diabetic retinopathy. Patients with high enzyme levels would need to be closely followed up in the management of the retinal complication. (C) 1997 Elsevier Science Ireland Ltd.