Regulation of Interleukin-10 Expression
Regulation of Interleukin-10 Expression
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DOI：
10.1007/978-94-024-0921-5_5
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Ouyang, Wenjun
中科院分区：
文献类型：
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作者：
Rutz, Sascha;Ouyang, Wenjun
白细胞介素(IL)-10是一种重要的抗炎细胞因子，在微生物抗原的免疫应答中起负调节作用。IL-10的缺失导致炎症性肠病的自发发展，这是对肠道微生物群过度免疫反应的结果。IL-10在感染过程中也有防止过度炎症的功能，几乎所有的免疫细胞，包括T细胞、B细胞、巨噬细胞和树突状细胞，都可以在对促炎信号的反应中产生IL-10。鉴于其在维持有效免疫和组织保护之间微妙平衡的功能，IL-10的表达显然是高度动态的，需要严格调节。本文就骨髓细胞和T细胞中IL-10产生的转录调控作一综述。我们将讨论IL-10表达的驱动因素及其下游信号通路和转录因子。我们将更详细地研究CD4(+) T细胞中的各种信号如何汇聚在共同的转录回路上，这些转录回路以一种依赖于环境的方式调节IL-10的表达。
Inierleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota. IL-10 also functions to prevent excessive inflammation during the course of infection, IL-10 can be produced in response to pro-inflammatory signals by virtually all immune cells, including T cells, B cells, macrophages, and dendritic cells. Given its function in maintaining the delicate balance between effective immunity and tissue protection, it is evident that IL-10 expression is highly dynamic and needs to be tightly regulated. The transcriptional regulation of IL-10 production in myeloid cells and T cells is the topic of this review. Drivers of IL-10 expression as well as their downstream signaling pathways and transcription factors will be discussed, We will examine in more detail how various signals in CD4(+) T cells converge on common transcriptional circuits, which line-tune IL-10 expression in a context dependent manner.