Safety and immunogenicity in neonatal mice of a hyperattenuated Listeria vaccine directed against human immunodeficiency virus.
Safety and immunogenicity in neonatal mice of a hyperattenuated Listeria vaccine directed against human immunodeficiency virus.
复制标题
针对人类免疫缺陷病毒的超减毒李斯特菌疫苗对新生小鼠的安全性和免疫原性。
DOI：
10.1128/jvi.76.2.918-922.2002
复制
发表时间：
2002
影响因子：
5.4
通讯作者：
Frankel,FredR
中科院分区：
文献类型：
--
作者：
Rayevskaya,Marina;Kushnir,Natasha;Frankel,FredR
CD8+T cells are a major component of the adaptive response of a host to infections by viruses and other intracellular pathogenic agents. However, because of the intrinsic immaturity of the immune system of neonatal animals, neonates are highly sensitive to a variety of pathogens and may be unable to respond in a protective manner. Here we explore whether a hyperattenuated strain ofListeria monocytogenesthat can be used as a live vaccine vector in adults is safe and able to induce an effective response in neonates. We answer both questions affirmatively.
