LncRNA GClnc1 promotes proliferation and invasion of bladder cancer through activation of MYC
LncRNA GClnc1 promotes proliferation and invasion of bladder cancer through activation of MYC
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DOI：
10.1096/fj.201900078rr
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发表时间：
2019-10-01
期刊：
影响因子：
4.8
通讯作者：
Gui, Yaoting
中科院分区：
文献类型：
--
作者：
Zhuang, Chengle;Ma, Qian;Gui, Yaoting
各种研究表明，长非编码 RNA (lncRNA) 在癌症中充当癌基因或肿瘤抑制因子。然而，lncRNA 在膀胱癌中的功能仍然很大程度上未知。在这项研究中，我们鉴定了一种 lncRNA，即胃癌相关 lncRNA1 (GClnc1)，它在膀胱癌组织中含量很高，其表达与膀胱癌患者的较差生存率有关。体外和体内试验表明，GClnc1 显着促进膀胱癌的细胞增殖、转移和侵袭。从机制上讲，我们首先发现GClnc1与LIN28B结合，并通过LIN28B/let-7a/MYC途径促进骨髓细胞瘤原癌基因（MYC）的表达。简而言之，GClnc1 在膀胱癌中具有临床、功能和机制致癌性。 GClnc1可能是治疗膀胱癌的潜在靶点。-Zhang, C., Ma, Q., Zhuang, C., Ye, J., Zhuang, F., Gui, Y. LncRNA GClnc1通过激活MYC促进膀胱癌的增殖和侵袭。
Various studies demonstrate that long noncoding RNAs (lncRNAs) act as oncogenes or tumor suppressors in cancer. However, the function of lncRNAs in bladder cancer still remains largely unknown. In this study, we identified an lncRNA, gastric cancer-associated lncRNA1 (GClnc1), which was in high abundance in bladder cancer tissues and its expression was related to poor survival rates in patients with bladder cancer. In vitro and in vivo assays showed that GClnc1 significantly promoted cell proliferation, metastasis, and invasiveness in bladder cancer. Mechanistically, we first found that GClnc1 bound to LIN28B and promoted the expression of myelocytomatosis proto-oncogene (MYC) through the LIN28B/let-7a/MYC pathway. In short, GClnc1 is clinically, functionally, and mechanistically oncogenic in bladder cancer. GClnc1 may be a potential target for treating patients with bladder cancer.-Zhuang, C., Ma, Q., Zhuang, C., Ye, J., Zhang, F., Gui, Y. LncRNA GClnc1 promotes proliferation and invasion of bladder cancer through activation of MYC.