DISTINCTIVE CHROMOSOMAL-ABNORMALITIES IN HISTOLOGIC SUBTYPES OF NON-HODGKINS LYMPHOMA
DISTINCTIVE CHROMOSOMAL-ABNORMALITIES IN HISTOLOGIC SUBTYPES OF NON-HODGKINS LYMPHOMA
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DOI：
10.1056/nejm198211113072002
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
THEOLOGIDES, A
中科院分区：
文献类型：
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作者：
YUNIS, JJ;OKEN, MM;THEOLOGIDES, A
采用一种新的高分辨率染色体分析技术对44例非霍奇金淋巴瘤患者中42例的淋巴结活检标本进行了研究，并采用新的国际组织学公式和免疫学标记进行了分类。42例患者均检出克隆性染色体异常。三种复发性染色体畸变与某些组织学类型相关：19例滤泡性淋巴瘤患者中有16例发生18号和14号染色体易位（小裂细胞、混合细胞和大细胞）; 6例小无裂细胞患者中有5例出现8号和14号染色体易位（非伯基特氏）或大细胞免疫母细胞淋巴瘤; 11例小细胞淋巴细胞淋巴瘤患者中有4例为12三体。特征性染色体缺陷发生在某些淋巴瘤亚型中。高分辨率染色体分析有望成为提高对淋巴癌基本认识的重要工具。
Biopsy specimens of lymph nodes from 42 of 44 patients with non-Hodgkin''s lymphoma were studied with a new high-resolution technique for chromosomal analysis and were categorized with the new international histologic formulation and immunologic markers. Abnormalities of the clonal chromosomes were detected in all 42 patients. Three recurrent chromosomal aberrations correlated with certain histologic types: a translocation between chromosomes 18 and 14 in 16 of 19 patients with follicular lymphomas (small cleaved cell, mixed cell, and large cell); a translocation between chromosomes 8 and 14 in 5 of 6 patients with small noncleaved-cell (non-Burkitt''s) or large-cell immunoblastic lymphoma; and a trisomy 12 in 4 of 11 patients with small-cell lymphocytic lymphoma. Characteristic chromosomal defects occur in certain lymphoma subtypes. High-resolution chromosomal analysis promises to become an important tool in improving basic understanding of lymphoid cancers.