Anterior chamber angle measurement with anterior segment optical coherence tomography: A comparison between slit lamp OCT and Visante OCT
Anterior chamber angle measurement with anterior segment optical coherence tomography: A comparison between slit lamp OCT and Visante OCT
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DOI：
10.1167/iovs.07-1477
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发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Lam, Dennis Shun Chiu
中科院分区：
文献类型：
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作者：
Leung, Christopher Kai-Shun;Li, Haitao;Lam, Dennis Shun Chiu
目的.比较两种眼前节光学相干断层扫描（OCT）仪测量的前房角，并评价其一致性和观察者间的重复性。49名健康正常人的49只眼睛进行了研究。使用Visante眼前节OCT（Carl Zeiss Meditec，都柏林，CA）和裂隙灯OCT（SLOCT，Heidelberg Engineering，GmbH，Dossenheim，德国）对每例受试者随机选择的一只眼睛进行前房角成像，并由两名独立观察员进行测量。测量鼻角和颞角的开角距离（AOD 500）、小梁-虹膜角（TIA 500）和小梁-虹膜间隙面积（TISA 500）。评价了SLOCT和Visante OCT测量之间的一致性以及观察者间的再现性。Visante OCT和SLOCT测量的平均鼻/颞前房角为527 ± 249/572 ± 275 μ m（AOD），0.180 ± 0.091/0.193 ± 0.102 mm（2）（TISA）和38.1 ± 12.3/39.6 ± 13.2度（TIA）;和534 +/- 234/628 +/- 254 μ m（AOD）、0.191 +/- 0.089/0.217 +/- 0.093 mm（2）（TISA）和37.8 +/- 10.1/40.6 +/- 10.7度（TIA）。除颞侧TISA外，Visante OCT和SLOCT测量值之间无显著差异（P = 0.034）。Visante OCT的观察者间变异系数范围为4.4%-7.8%，SLOCT为4.9%-7.0%。对于AOD、TISA和TIA，Visante OCT和SLOCT之间鼻/颞角测量的95%一致性范围分别为437/531 mm（2）、0.174/0.186 mm（2）和25.3/28.0度。虽然Visante OCT和SLOCT证明了前房角测量的观察者间重现性较高，但一致性较差。
PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility.METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular-iris angle (TIA 500), and the trabecular-iris space area (TISA 500) at the nasal and temporal angles were measured. The agreements between SLOCT and Visante OCT measurements and the interobserver reproducibility were evaluated.RESULTS. The mean nasal/temporal anterior chamber angles measured by Visante OCT and SLOCT were 527 +/- 249/572 +/- 275 mu m (AOD), 0.180 +/- 0.091/0.193 +/- 0.102 mm(2) (TISA), and 38.1 +/- 12.3/39.6 +/- 13.2 degrees (TIA); and 534 +/- 234/628 +/- 254 mu m (AOD), 0.191 +/- 0.089/0.217 +/- 0.093 mm(2) (TISA), and 37.8 +/- 10.1/40.6 +/- 10.7 degrees (TIA), respectively. No significant difference was found between Visante OCT and SLOCT measurements except the temporal TISA (P = 0.034). The interobserver coefficient of variation ranged between 4.4% and 7.8% for Visante OCT and 4.9% and 7.0% for SLOCT. The spans of 95% limits of agreement of the nasal/temporal angle measurements between Visante OCT and SLOCT were 437/531 mm(2), 0.174/0.186 mm(2), and 25.3/28.0 degrees for AOD, TISA, and TIA, respectively.CONCLUSIONS. Although Visante OCT and SLOCT demonstrate high interobserver reproducibility for anterior chamber angle measurements, their agreement was poor.