Persistent infection with virulent but not avirulent Mycobacterium tuberculosis in the lungs of mice causes progressive pathology
Persistent infection with virulent but not avirulent Mycobacterium tuberculosis in the lungs of mice causes progressive pathology
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DOI：
10.1099/00222615-45-2-103
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发表时间：
1996-08-01
影响因子：
3
通讯作者：
North, RJ
中科院分区：
文献类型：
--
作者：
Dunn, PL;North, RJ
比较了一种被认为对小鼠有毒性的结核分枝杆菌菌株（H37Rv）和一种被认为相对无毒力的菌株（R1Rv）在肺部宿主免疫中存活和诱导肺部病理的能力。虽然两株M.结核菌株能够在免疫活性小鼠的肺中引起缓慢进行性感染，只有H37Rv菌株能够在300天的时间内诱导进行性破坏性病理学并引起肺功能丧失。因此，在肺中存活宿主免疫的能力和引起肺病理的能力是分枝杆菌毒力的单独表现。
A strain of Mycobacterium tuberculosis (H37Rv) considered virulent for mice and a strain (R1Rv) considered relatively avirulent were compared for their ability to survive host immunity in the lungs and to induce lung pathology. Although both strains of M. tuberculosis were capable of causing a slowly progressive infection in the Lungs of immunocompetent mice, only the H37Rv strain was capable of inducing progressive destructive pathology and of causing loss of lung function over a 300-day period. Therefore, the ability to survive host immunity in the lungs and the ability to cause lung pathology are separate manifestations of mycobacterial virulence.