Obesity-related glomerulopathy: An emerging epidemic
Obesity-related glomerulopathy: An emerging epidemic
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DOI：
10.1046/j.1523-1755.2001.0590041498.x
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发表时间：
2001-04-01
影响因子：
19.6
通讯作者：
D'Agati, VD
中科院分区：
文献类型：
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作者：
Kambham, N;Markowitz, GS;D'Agati, VD
背景我们报告了第一个基于大肾活检的肥胖相关性肾小球病的临床病理研究。肥胖定义为体重指数（BMI）>30 kg/m2。肥胖相关性肾小球病（ORG）在形态学上定义为局灶节段性肾小球硬化和肾小球肥大（O-FSGS; N = 57）或单纯肾小球肥大（O-GM; N = 14）。回顾1986 - 2000年收到的6818例自体肾活检，发现ORG的活检发生率从1986-1990年的0.2%逐渐增加到1996-2000年的2.0%（P = 0.0001）。ORG的平均BMI为41.7（范围30.9至62.7）。肾活检指征包括蛋白尿（N = 40）或蛋白尿合并肾功能不全（N = 31）。将71例ORG患者与50例特发性FSGS（I-FSGS）患者进行比较。ORG患者年龄较大（平均42.9对32.6，P < 0.001），且更常见于白人（75%对52%; P = 0.003）。ORG患者肾病范围蛋白尿（48% vs. 66%; P = 0.007）和肾病综合征（5.6% vs. 54%; P < 0.001）的发生率较低，血清白蛋白（3.9 vs. 2.9 g/dL; P
Background. We report the first large renal biopsy-based clinicopathologic study on obesity-related glomerulopathy.Methods. Obesity was defined as body mass index (BMI) >30 kg/m(2) Obesity-related glomerulopathy (ORG) was defined morphologically as-focal segmental glomerulosclerosis and glomerulomegaly (O-FSGS; N = 57) or glomerulomegaly alone (O-GM; N = 14);Results. Review of 6818 native renal biopsies received from 1986 to 2000 revealed a progressive increase in biopsy incidence of ORG from 0.2% in 1986-1990 to 2.0% in 1996-2000 (P = 0.0001). Mean BMI in ORG was 41.7 (range 30.9 to 62.7). Indications for genal biopsy included proteinuria (N = 40) or proteinuria and renal insufficiency (N = 31). Seventy-one patients with ORG were compared to 50 patients with idiopathic FSGS (I-FSGS) Patients with ORG were older (mean 42.9 vs. 32.6 frears, P < 0.001) and more often Caucasian (75% vs. 52%; P = 0.003). ORG patients had a lower incidence of nephrotic range proteinuria (48% vs. 66%; P = 0.007) and nephrotic syndrome(5.6% vs 54%; P < 0.001), with higher serum albumin (3.9 vs. 2.9 g/dL; P