Fe-Catalyzed Reductive Coupling of Unactivated Alkenes with β-Nitroalkenes.
Fe-Catalyzed Reductive Coupling of Unactivated Alkenes with β-Nitroalkenes.
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DOI：
10.1021/acs.orglett.5b02294
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发表时间：
2015-09
期刊：
影响因子：
5.2
通讯作者：
Jing Zheng;Dahai Wang;Sunliang Cui
中科院分区：
文献类型：
--
作者：
Jing Zheng;Dahai Wang;Sunliang Cui
发展了铁催化未活化烯烃与β-硝基烯烃的还原偶联反应。该反应通过自由基途径进行，β-硝基烯烃充当乙烯化试剂，并且硝基在该过程中被裂解。因此，这种方法提供了一个可行的合成方法，有价值的仲和叔烷基化苯乙烯衍生物。此外，进行了控制实验，并提出了一个合理的机制。
An Fe-catalyzed reductive coupling of unactivated alkenes with β-nitroalkenes has been developed. The reaction proceeds through a radical pathway, with β-nitroalkenes serving as the vinylating reagents and the nitro group being cleaved in the process. Therefore, this method provides a viable synthetic approach to valuable secondary- and tertiary-alkylated styrene derivatives. Furthermore, control experiments were conducted and a plausible mechanism is proposed.