Iron-Catalyzed Oppenauer-Type Oxidation of Alcohols
Iron-Catalyzed Oppenauer-Type Oxidation of Alcohols
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DOI：
10.1002/adsc.200900896
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发表时间：
2010-04-01
影响因子：
5.4
通讯作者：
Guan, Hairong
中科院分区：
文献类型：
--
作者：
Coleman, Michael G.;Brown, Alec N.;Guan, Hairong
一个（羟基）铁二羰基氢化物催化奥本诺尔型氧化醇与丙酮作为氢受体。许多官能团耐受氧化条件。同样的络合物也催化二醇脱氢为内酯。提出了铁-醇络合物的形成及其与游离醇的快速配体交换机制。催化剂的三甲基硅基配体上的三甲基硅基在稳定氢化铁和增加催化剂寿命方面起着关键作用。
A (hydroxycyclopentadienyl)iron dicarbonyl hydride catalyzes the Oppenauer-type oxidation of alcohols with acetone as the hydrogen acceptor. Many functional groups are tolerant to the oxidation conditions. The same complex also catalyzes the dehydrogenation of diols to lactones. A mechanism involving the formation of iron-alcohol complexes and their rapid ligand exchange with free alcohols is proposed. The trimethylsilyl groups on the cyclopentadienyl ligand of the catalyst play a critical role in stabilizing the iron hydride and increasing the catalyst lifetime.